Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Niaprazine is a histamine H1-receptor antagonist with marked sedative properties.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
無料サンプル 1 mg | |||||
1 mg | 在庫あり | ¥ 9,500 | |||
2 mg | 在庫あり | ¥ 13,000 | |||
5 mg | 在庫あり | ¥ 20,500 | |||
10 mg | 在庫あり | ¥ 34,000 | |||
25 mg | 在庫あり | ¥ 57,000 | |||
50 mg | 在庫あり | ¥ 85,000 | |||
100 mg | 在庫あり | ¥ 125,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 22,500 |
説明 | Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. |
ターゲット&IC50 | 5-HT2:25 nM(Ki), α1-adrenergic receptor:77 nM(Ki) |
In vitro | Niaprazine exhibits a low affinity for the vesicular monoamine transporter and for D2, α2, β, H1 and mAch receptors. Niaprazine, particularly the (+)stereoisomer, has a higher affinity for α1 (Ki = 77 nM) and 5-HT2 (Ki = 25 nM) binding sites, but is poorly recognized by 5-HT1A and 5-HT1B binding sites[2]. |
In vivo | Niaprazine (60 mg/kg; i.p.; once) treatment increases rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Niaprazine also produces a short-lasting depletion of rat brain noradrenaline (NA) and dopamine (DA)[3]. Animal Model: Male Sprague-Dawley rats (150-200 g)[3] |
分子量 | 356.44 |
分子式 | C20H25FN4O |
CAS No. | 27367-90-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (280.55 mM)
You can also refer to dose conversion for different animals. 詳細
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Niaprazine 27367-90-4 GPCR/G Protein Immunology/Inflammation Neuroscience Adrenergic Receptor 5-HT Receptor Histamine Receptor 5-HIAA disorders sleep autistic inhibit 5-HT2 sedative Inhibitor H1-receptor inhibitor