Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PD128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 10,500 |
5 mg | 在庫あり | ¥ 24,500 |
10 mg | 約5 days | ¥ 38,000 |
25 mg | 約5 days | ¥ 64,000 |
50 mg | 約5 days | ¥ 95,000 |
説明 | PD128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. |
ターゲット&IC50 | D3 receptor:0.64 nM (Ki) |
In vitro | PD128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. [1] When using [3H]spiperone as the radioligand in CHOKl-cells, PD 128907 exhibits about a l000-fold selectivity for human D3 receptors (Ki, 1 nM) versus human D2 receptors (Ki, 1183 nM) and a l0000-fold selectivity versus human D4receptors (Ki, 7000 nM) [2] PD 128907 is used for studying the role of these receptors in the brain, in roles such as inhibitory autoreceptors that act to limit further dopamine release.[3] |
In vivo | PD128907 HCl is active in reducing DA synthesis both in normal and γ-butyrolactone (GBL) treated rats. [4] PD128907 HCl (3 mg/kg) reduces toxicity from cocaine overdose, completely prevented the convulsant and lethal effects of cocaine. [5] The protection occurs through a D3-linked mechanism and that protection is extended to seizure kindling. [6] |
分子量 | 285.77 |
分子式 | C14H20ClNO3 |
CAS No. | 112960-16-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: <1 mg/mL
H2O: 46 mg/mL (161 mM)
DMSO: 10 mg/mL (35 mM)
You can also refer to dose conversion for different animals. 詳細
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PD128907 HCl 112960-16-4 GPCR/G Protein Neuroscience Dopamine Receptor PD-128907 HCl Inhibitor inhibitor inhibit