Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).
説明 | PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM). |
ターゲット&IC50 | PHD1:0.034 μM |
In vivo | Administration of PHD-1-IN-1 (3 mg/kg of p.o. or 0.5 mg/kg of i.v.) has a Cmax of 0.8 μM, a AUC of 176 ng?h/mL, Kp,uu of 1.11 and B/P of 0.95[1]. |
分子量 | 220.23 |
分子式 | C13H8N4 |
CAS No. | 2009343-14-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (49.95 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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PHD-1-IN-1 2009343-14-8 Chromatin/Epigenetic Metabolism HIF/HIF Prolyl-Hydroxylase pocket ion Arg367-out HIF-PH Hypoxia-inducible factors site active PHD 1 IN 1 orally Inhibitor PHD-1 Fe2+ PHD1IN1 iron HIFs inhibit inhibitor