Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 22,500 | |||
10 mg | 在庫あり | ¥ 37,000 | |||
25 mg | 在庫あり | ¥ 74,500 | |||
50 mg | 在庫あり | ¥ 123,500 | |||
100 mg | 在庫あり | ¥ 149,000 | |||
500 mg | 在庫あり | ¥ 317,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 20,000 |
説明 | PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor. |
ターゲット&IC50 | CSF1R:0.016 µM (IC50), CSF1R:Ki: 5.9 nM |
In vivo | Treated pregnant dams with the CSF1R inhibitor PLX-5622. Approximately 99% of microglia were eliminated by embryonic day 15.5 (E15.5) after pregnant dams were placed on a PLX-5622 diet starting at E3.5. Following microglia depletion, Elevated numbers of apoptotic cells accumulating throughout the developing hypothalamus. Once the PLX-5622 diet was removed, microglia repopulated the postnatal brain within 7?days and did not appear to repopulate from Nestin+?precursors[1]. |
別名 | PLX-5622 |
分子量 | 395.41 |
分子式 | C21H19F2N5O |
CAS No. | 1303420-67-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 79 mg/mL (199.79 mM)
You can also refer to dose conversion for different animals. 詳細
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PLX5622 1303420-67-8 Tyrosine Kinase/Adaptors c-Fms CSF-1R Inhibitor CSF-1 receptor PLX-5622 microglial PLX 5622 CSF1R orally pathology inhibit penetrant preceding brain colony stimulating factor 1 receptor elimination inhibitor