Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 degrader-1, a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM.
パッケージサイズ | 在庫状況 | 単価(税別) | |
---|---|---|---|
1 mg | お問い合わせ | ¥ 105,000 | |
5 mg | お問い合わせ | ¥ 186,500 | |
10 mg | お問い合わせ | ¥ 284,500 | |
50 mg | お問い合わせ | お問い合わせ | |
100 mg | お問い合わせ | お問い合わせ |
説明 | PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 degrader-1, a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM. |
ターゲット&IC50 | MCL1:0.78 μM |
分子量 | 909.84 |
分子式 | C45H45BrN6O8S |
CAS No. | 2163793-38-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (54.95 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. 詳細
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PROTAC Mcl1 degrader-1 2163793-38-0 Apoptosis BCL PROTAC Mcl-1 degrader-1 PROTAC Mcl1 degrader 1 PROTAC Mcl1 degrader1 Inhibitor inhibitor inhibit