Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 27,000 | |||
5 mg | 在庫あり | ¥ 66,000 | |||
10 mg | 在庫あり | ¥ 114,000 | |||
25 mg | 在庫あり | ¥ 182,000 | |||
50 mg | 在庫あり | ¥ 259,500 | |||
100 mg | 在庫あり | ¥ 349,000 | |||
500 mg | 在庫あり | ¥ 682,000 |
説明 | Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity. |
ターゲット&IC50 | Aurora A:31 nM |
In vitro | Phthalazinone pyrazole potently inhibited the activity of Aurora A kinase with an IC50 of 31 nM. It showed no inhibitory effect on Aurora B kinase at doses up to 100 μM. Phthalazinone pyrazole inhibited the proliferation of HCT116, Colo205, and MCF-7 cells with IC50 values of 7.8, 2.9, and 1.6 μM, respectively [1]. |
分子量 | 317.34 |
分子式 | C18H15N5O |
CAS No. | 880487-62-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
You can also refer to dose conversion for different animals. 詳細
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Phthalazinone pyrazole 880487-62-7 Cell Cycle/Checkpoint Chromatin/Epigenetic Aurora Kinase inhibit human embryonic stem cells hepatocyte-like cell Inhibitor HLCs Aurora-A kinase EMT apoptosis tumor growth oral epithelial-mesenchymal transition inhibitor