Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and downregulation of androgen receptor expression. Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-κB survival pathway in A375-S2 cells.
説明 | Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and downregulation of androgen receptor expression. Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-κB survival pathway in A375-S2 cells. |
植物由来 |
分子量 | 526.538 |
分子式 | C28H30O10 |
CAS No. | 23027-91-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Physalin A 23027-91-0 Angiogenesis Apoptosis Autophagy Chromatin/Epigenetic Endocrinology/Hormones Immunology/Inflammation JAK/STAT signaling MAPK NF-Κb Stem Cells STAT JNK JAK p53 ROS NF-κB Androgen Receptor p38 MAPK ERK BCL Inhibitor inhibitor inhibit