Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
無料サンプル 1 mg | |||||
1 mg | 在庫あり | ¥ 7,000 | |||
2 mg | 在庫あり | ¥ 10,000 | |||
5 mg | 在庫あり | ¥ 14,000 | |||
10 mg | 在庫あり | ¥ 19,500 | |||
25 mg | 在庫あり | ¥ 34,500 | |||
50 mg | 在庫あり | ¥ 53,000 | |||
100 mg | 在庫あり | ¥ 85,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 16,500 |
説明 | Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. |
ターゲット&IC50 | ERK1:98 nM(Kd), RasGAP:212 nM(Kd) |
In vitro | SC1 is a dual function small molecule inhibitor of both ERK1 and RasGAP and that simultaneous inhibition of both protein activities is required and sufficient for SC1's effects on mES cells. SC1 activates Ras by inhibition of RasGAP function[1]. SC1 improved the derivation efficiency and pluripotency of ES cells from C57BL/6. Three types of pluripotent stem cells (fES, ntES, and iPS cells) of the C57BL/6 background could generate full-term pups with high efficiency when cultured with SC1[1]. |
別名 | SC1 |
分子量 | 550.53 |
分子式 | C27H25F3N8O2 |
CAS No. | 839707-37-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 13.8 mg/mL (25 mM)
You can also refer to dose conversion for different animals. 詳細
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Pluripotin 839707-37-8 MAPK PI3K/Akt/mTOR signaling Raf ERK S6 Kinase inhibit Extracellular signal regulated kinases Ribosomal S6 Kinase (RSK) Inhibitor SC-1 SC1 S6K SC 1 inhibitor