Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).
説明 | RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively). |
ターゲット&IC50 | p53-MDMX:~24 nM, p53-MDM2:~17 nM |
In vitro | RO-5963 (10 μM, 24 hours) potently activates p53 and elevates p21 and MDM2 levels. RO-5963 (10-20 μM; 48 hours) displays much higher apoptotic activity than Nutlin in both MCF7 and ZR75-30 cell lines [1]. |
分子量 | 518.9 |
分子式 | C24H21ClF2N4O5 |
CAS No. | 1416663-77-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (96.36 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
RO-5963 1416663-77-8 Apoptosis Mdm2 p53 RO 5963 RO5963 Inhibitor inhibitor inhibit