Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It is over 1,000-fold less potent against the cyclin B/CDK1 complex.
ターゲット&IC50 | CDK4:10 nM, CDK6:39 nM |
In vivo | Treatment with Ribociclib (200 mg/kg) daily for 21 days significantly delays tumor growth in CB17 immunodeficient mice bearing BE2C or NB-1643 (MYCN amplified, sensitive in vitro) xenografts, with notable effects observed through the treatment period (p<0.0001 for both). However, tumor growth resumes after cessation of treatment. The regimen, also applied to EBC1 (non-amplified, resistant in vitro) xenografts for comparison, demonstrates a favorable safety profile across all xenograft models, indicated by the absence of weight loss or toxicity signs [2]. |
別名 | LEE011 hydrochloride |
分子量 | 471 |
分子式 | C23H31ClN8O |
CAS No. | 1211443-80-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mg/mL (21.23 mM), Sonification is recommended.
DMSO: 7.69 mg/mL (16.33 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Ribociclib hydrochloride 1211443-80-9 Cell Cycle/Checkpoint CDK LEE-011 Hydrochloride LEE011 hydrochloride LEE011 Hydrochloride Ribociclib Hydrochloride LEE 011 Hydrochloride Inhibitor inhibitor inhibit