Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ruboxistaurin hydrochloride (LY 333531 hydrochloride) is an Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKCβ over other PKC isozymes (IC50values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 μM for PKCη, -δ, -γ, -α, -ε and -ζ respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src).
説明 | Ruboxistaurin hydrochloride (LY 333531 hydrochloride) is an Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKCβ over other PKC isozymes (IC50values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 μM for PKCη, -δ, -γ, -α, -ε and -ζ respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src). |
ターゲット&IC50 | PKCη:0.052 μM, PKCβ2:5.9 nM, PKCδ:0.25 μM, PKCγ:0.3 μM, PKCβ1:4.7 nM |
別名 | Ruboxistaurin, LY333531 HCl, LY 333531 hydrochloride |
分子量 | 505.01 |
分子式 | C28H28N4O3·HCl |
CAS No. | 169939-93-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10.1 mg/mL (20 mM)
You can also refer to dose conversion for different animals. 詳細
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Ruboxistaurin hydrochloride 169939-93-9 Chromatin/Epigenetic Cytoskeletal Signaling PKC Ruboxistaurin Hydrochloride LY 333531 LY333531 Ruboxistaurin LY-333531 LY-333531 Hydrochloride LY 333531 Hydrochloride LY333531 HCl Inhibitor LY 333531 hydrochloride inhibit LY333531 Hydrochloride Protein kinase C inhibitor