Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 25,500 |
5 mg | 約 35 days | ¥ 68,000 |
10 mg | 約 35 days | ¥ 111,000 |
25 mg | 約 35 days | ¥ 243,500 |
説明 | SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively). |
ターゲット&IC50 | 5-HT1D receptor:5.9(pki), D2 receptor:6 (pki), 5-HT1B receptor:<5.2 (pki), D3 receptor:pki: 8.0 |
In vitro | SB-277011 dihydrochloride is a selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor, and restores ≥100-fold selectivity against the D2, 5-HT1B, and 5-HT1D receptors(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively). |
In vivo | the effects of quinelorane in the nucleus accumbens completely reversed by SB-277011 dihydrochloride (SB 277011; 3 mg/kg, p.o.), but does not reverse the effects of quinelorane in the striatum at 93 mg/kg in rats. |
別名 | SB-277011A dihydrochloride |
分子量 | 511.49 |
分子式 | C28H32Cl2N4O |
CAS No. | 1226917-67-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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SB-277011 dihydrochloride 1226917-67-4 GPCR/G Protein Neuroscience Dopamine Receptor SB-277011A SB-277011 SB277011 Dihydrochloride SB-277011A Dihydrochloride SB277011 dihydrochloride SB-277011 Dihydrochloride SB277011 SB 277011 Dihydrochloride SB-277011A dihydrochloride SB 277011 dihydrochloride SB 277011 Inhibitor inhibitor inhibit