Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
無料サンプル 1 mg | |||||
5 mg | 在庫あり | ¥ 10,000 | |||
10 mg | 在庫あり | ¥ 17,000 | |||
25 mg | 在庫あり | ¥ 37,500 | |||
50 mg | 在庫あり | ¥ 64,000 | |||
100 mg | 在庫あり | ¥ 112,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 14,000 |
説明 | SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM). |
ターゲット&IC50 | C3a:200 nM |
In vitro | SB 290157 is a competitive antagonist of 125I-C3a radioligand binding to rat basophilic leukemia-2H3 cells expressing the human C3aR (RBL-C3aR, IC50 of 200 nM). SB 290157 blocks C3a-induced C3aR internalization in a concentration-dependent manner and C3a-induced Ca2+ mobilization in RBL-C3aR cells and human neutrophils (IC50s of 27.7 and 28 nM, respectively). SB 290157 is selective for the C3aR in that. SB 290157 also inhibits C3a-induced Ca2+ mobilization of RBL-2H3 cells expressing the mouse and guinea pig C3aRs. It potently inhibits C3a-mediated ATP release from guinea pig platelets and inhibits C3a-induced potentiation of the contractile response to field stimulation of perfused rat caudal artery[1]. |
In vivo | Neutrophil recruitment in a guinea pig LPS-induced airway neutrophilia model inhibited by SB 290157 ,SB 290157 decreases paw edema in a rat adjuvant-induced arthritis model[1]. The antagonist is able to reduce joint swelling only at 3 h, and about 50% inhibition of joint swelling is observed with the concentration of 30 mg/kg. The C3 level is significantly decreased at 3 h compared with naive mice showing complement consumption. Furthermore, the C3 activation is observed and increased corresponding to the graded concentration of anti-OVA pAb[2]. |
分子量 | 526.51 |
分子式 | C24H29F3N4O6 |
CAS No. | 1140525-25-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (237.41 mM), sonification is recommended.
You can also refer to dose conversion for different animals. 詳細
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SB290157 trifluoroacetate 1140525-25-2 Immunology/Inflammation Complement System SB290157 Trifluoroacetate SB290157 SB-290157 trifluoroacetate Inhibitor SB 290157 Trifluoroacetate inhibit SB 290157 SB-290157 SB-290157 Trifluoroacetate inhibitor