Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TCS 21311 (NIBR3049) is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM). TCS 21311 inhibits PKCα, PKCθ, and GSK3β (IC50s: 13, 68, and 3 nM, respectively). It displays >100-fold selectivity over JAK1, JAK2, and TYK2.
説明 | TCS 21311 (NIBR3049) is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM). TCS 21311 inhibits PKCα, PKCθ, and GSK3β (IC50s: 13, 68, and 3 nM, respectively). It displays >100-fold selectivity over JAK1, JAK2, and TYK2. |
ターゲット&IC50 | JAK2:2.55 μM, PKCα:13 nM, JAK1:1.017 μM, PKCθ:68 nM, JAK3:8 nM, GSK-3β:3 nM |
別名 | NIBR3049 |
分子量 | 526.51 |
分子式 | C27H25F3N4O4 |
CAS No. | 1260181-14-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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TCS 21311 1260181-14-3 Angiogenesis Chromatin/Epigenetic Cytoskeletal Signaling JAK/STAT signaling PI3K/Akt/mTOR signaling Stem Cells GSK-3 JAK PKC Protein kinase C Glycogen synthase kinase 3 TCS21311 Glycogen synthase kinase-3 Inhibitor TCS-21311 inhibit NIBR-3049 NIBR3049 Janus kinase NIBR 3049 inhibitor