TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.
| 説明 | TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles. |
| ターゲット＆IC50 | ALK5:2.72 nM |
| 別名 | TP427736, TP-0427736, TP-427736 |
| 分子量 | 298.39 |
| 分子式 | C14H10N4S2 |
| CAS No. | 864374-00-5 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 65 mg/ml (217.84 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
参考文献
投与量変換You can also refer to dose conversion for different animals. 詳細
In vivo投与量計算 (透明溶液)計算器bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TP0427736 864374-00-5 Stem Cells TGF-beta/Smad TP427736 TP-0427736 TP-427736 Inhibitor inhibitor inhibit
