Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |
---|---|---|---|
1 mg | 在庫あり | ¥ 37,500 | |
5 mg | 在庫あり | ¥ 125,500 | |
10 mg | 在庫あり | ¥ 190,000 | |
25 mg | 在庫あり | ¥ 282,500 | |
50 mg | お問い合わせ | お問い合わせ | |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 154,500 |
説明 | TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM). |
ターゲット&IC50 | PKC:11.9 nM (ki) |
In vitro | TPPB inhibits the activation of caspase-3 induced by Aβ25-35. TPPB could increase the phosphorylation of Akt, PKC, MARCKS, and MAPK, which are inhibited by Aβ25-35 treatment. TPPB at a concentration of 1 μM could antagonize Aβ25-35 induced cell damage. By the use of a cell line derived from an Alzheimer’s disease patient, significant enhancement of sAPPα secretion is achieved at 1 μM concentration for TPPB. TPPB has a role against Aβ25-35-induced neurotoxicity in PC12 cells [1][2]. |
In vivo | TPPB is evaluated for the induction of hyperplasia displays a modest response at 300 μg after topical application to the shaved backs of outbred Sencar mice and [1]. |
分子量 | 501.54 |
分子式 | C27H30F3N3O3 |
CAS No. | 497259-23-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (249.23 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. 詳細
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TPPB 497259-23-1 Chromatin/Epigenetic Cytoskeletal Signaling PKC Protein kinase C inhibit Inhibitor inhibitor