Powder: -20°C for 3 years | In solvent: -80°C for 1 year
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
無料サンプル 1 mg | |||||
5 mg | 在庫あり | ¥ 12,000 | |||
10 mg | 在庫あり | ¥ 18,500 | |||
25 mg | 在庫あり | ¥ 33,000 | |||
50 mg | 在庫あり | ¥ 53,500 | |||
100 mg | 在庫あり | ¥ 91,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,500 |
説明 | URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM). |
ターゲット&IC50 | MLK2:42nM, DLK:150 nM, MLK3:14nM, MLK1:19nM |
キナーゼ試験 | HDAC IC50 Profiling: The in vitro inhibitory activity of compounds against seven human HDAC isoforms (1, 2, 4 C2A, 5 C2A, 6, 8, and 11) are performed with a fluorescent based assay according to the company's standard operating procedure. The IC50 values are determined using 10 different concentrations with 3-fold serial dilution starting at 10 μM. TSA and vorinostat are used as reference compounds. |
分子量 | 421.54 |
分子式 | C27H27N5 |
CAS No. | 1229582-33-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 6 mg/mL (14.2 mM)
DMSO: 75 mg/mL (177.9 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
URMC-099 1229582-33-5 Angiogenesis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair MAPK Metabolism Stem Cells Tyrosine Kinase/Adaptors Aurora Kinase Src Bcr-Abl CDK LRRK2 MEK Trk receptor c-Met/HGFR Syk IGF-1R MLK VEGFR SGK DNA Alkylation ROCK inhibit MLKs URMC099 URMC 099 Inhibitor Mixed Lineage Kinase inhibitor