Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Y-33075 is a selective inhibitor of ROCK derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 約 5 days | ¥ 26,000 |
25 mg | 約6-8 週間 | ¥ 176,000 |
50 mg | 約6-8 週間 | ¥ 228,500 |
100 mg | 約6-8 週間 | ¥ 374,000 |
1 mL * 10 mM (in DMSO) | 約 5 days | ¥ 75,500 |
ターゲット&IC50 | PKC:420 nM, ROCK:3.6 nM, CaMK II:810 nM |
In vivo | Y-39983, when administered topically at concentrations of 0.01% or higher, significantly reduces intraocular pressure (IOP) in rabbits within 2 hours. In monkeys, eyes treated with 0.05% Y-39983 demonstrate a substantial decrease in IOP from 2 to 7 hours post-administration. Additionally, at a concentration of 100 μM, Y-39983 fosters the growth of regenerating axons in the retinal ganglion cells (RGCs) of rats. |
別名 | Y 39983 |
分子量 | 280.32 |
分子式 | C16H16N4O |
CAS No. | 199433-58-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (178.37 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Y-33075 199433-58-4 Chromatin/Epigenetic Cytoskeletal Signaling PKC Y 39983 Y33075 Y-39983 Y39983 Y 33075 Inhibitor inhibitor inhibit