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Disitamab vedotin (RC-48) is an antibo-active molecular conjugate (ADC) containing a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) that binds to the cytotoxic agent MMAE via a degradable linker. Disitamab vedotin showed anti-tumor and anti-proliferation activities in gastric cancer cells with different HER-2 expression levels, and inhibited the expression of HER-2 protein in gastric cancer cells.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 80,000 |
5 mg | 在庫あり | ¥ 192,500 |
10 mg | 在庫あり | ¥ 266,500 |
25 mg | 在庫あり | ¥ 395,000 |
50 mg | 在庫あり | ¥ 532,500 |
説明 | Disitamab vedotin (RC-48) is an antibo-active molecular conjugate (ADC) containing a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) that binds to the cytotoxic agent MMAE via a degradable linker. Disitamab vedotin showed anti-tumor and anti-proliferation activities in gastric cancer cells with different HER-2 expression levels, and inhibited the expression of HER-2 protein in gastric cancer cells. |
In vitro | The antibody component was a humanized monoclonal antibody designed to target HER2, while the small molecule toxin utilized was monomethyl auristatin E (MMAE), a synthetic antineoplastic agent. A protease-cleavable linker was used to covalently attach MMAE to the antibody.[2] |
別名 | RC 48, RC-48, RC48 |
分子量 | N/A |
CAS No. | 2136633-23-1 |
store at low temperature,keep away from direct sunlight
store at -20°C
You can also refer to dose conversion for different animals. 詳細
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Disitamab vedotin 2136633-23-1 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR RC 48 RC-48 RC48 Inhibitor inhibitor inhibit