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Guselkumab (CNTO 1959) is a recombinant human IgG1 monoclonal antibody targeting the IL-23p19 subunit. Guselkumab binds to human cynomolgus monkey IL-23 with Kd values of 3.3 and 1.9 pmol/L, respectively. Guselkumab can inhibit the production of cytokines downstream of IL-23 signaling pathway, and can be used in the study of psoriatic arthritis.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 152,500 |
5 mg | 在庫あり | ¥ 532,500 |
10 mg | 在庫あり | ¥ 716,000 |
25 mg | 在庫あり | ¥ 1,062,500 |
50 mg | 在庫あり | ¥ 1,439,000 |
100 mg | 在庫あり | ¥ 1,941,500 |
説明 | Guselkumab (CNTO 1959) is a recombinant human IgG1 monoclonal antibody targeting the IL-23p19 subunit. Guselkumab binds to human cynomolgus monkey IL-23 with Kd values of 3.3 and 1.9 pmol/L, respectively. Guselkumab can inhibit the production of cytokines downstream of IL-23 signaling pathway, and can be used in the study of psoriatic arthritis. |
ターゲット&IC50 | IL-23:0.06 nM (IC50), IL-23 (human):3.3 pM, IL-23 (monkey):1.9 pM, IL-23:0.06 pM(kd), STAT3 phosphorylation:102.1100±2.0053 nM |
In vitro | Guselkumab effectively suppresses the production of Th17 cytokines, including IL17A, IL-17F, and IL-22, in mouse splenocytes stimulated with IL-23 concentrations of 0.5 or 1 ng/mL, demonstrating IC50 values between 0.016-0.080 nM. It also inhibits the IL-23 (10 or 100 ng/mL) driven production of IL-10 in human NKL cells. However, guselkumab does not impact the IL-12 (0.1 ng/mL) mediated production of interferon γ (IFNγ) in NK92MI cells. In combination with IBI112, guselkumab can prevent IL-23-induced STAT3 phosphorylation, showing an IC50 of 102.1100±2.0053 nM. Additionally, guselkumab blocks the induction of mIL-17 production by hIL-23 in a dose-dependent manner with an IC50 of 4.9743 ±1.2847 nM and inhibits IL-17F production in cynomolgus monkeys with an IC50 of 16.7950 nM. |
別名 | CNTO 1959 |
分子量 | N/A |
分子式 | N/A |
CAS No. | 1350289-85-8 |
store at low temperature
store at -80°C
You can also refer to dose conversion for different animals. 詳細
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Guselkumab 1350289-85-8 Immunology/Inflammation IL Receptor CNTO1959 CNTO 1959 CNTO-1959 Inhibitor inhibitor inhibit