Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 values of 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.
説明 | H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 values of 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively. |
ターゲット&IC50 | ROCK2 (cell-free assay):0.0120 μM, PKG (cell-free assay):0.360 μM, Aurora A (cell-free assay):0.745 μM, CaMK II (cell-free assay):0.180 μM, PKA (cell-free assay):3.03 μM |
In vitro | H-1152 dihydrochloride shows less inhibitory activities against Src, MLCK, Abl, EGFR, MKK4, GSK3α, AMPK, and P38α, with IC50s of 3.06, 28.3, 7.77, 50.0, 16.9, 60.7, 100, and 100 μM, respectively[1]. H-1152 dihydrochloride slightly suppresses PKA, PKC and MLCK, with Kis of 0.63, 9.27, and 10.1 μM, respectively. In LPA-treated cells, H-1152 dihydrochloride (0.1-10 µM) inhibits MARCKS phosphorylation (IC50 = 2.5 µM)[2]. H-1152 dihydrochloride (0.5-10 μM) does not decrease neuronal survival or alter the ratios of different neuronal morphologies. H-1152 dihydrochloride (10 μM) arguments neurite length in both BMP4 and LIF cultures[3]. |
別名 | H-1152 2HCl, H-1152 dihydrochloride |
分子量 | 392.34 |
分子式 | C16H23Cl2N3O2S |
CAS No. | 871543-07-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (114.7 mM ), Sonification is recommended.
H2O: 32.1 mg/mL (81.9 mM ), Sonification is recommended.
You can also refer to dose conversion for different animals. 詳細
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H-1152 dihydrochloride 871543-07-6 Cell Cycle/Checkpoint Cytoskeletal Signaling Stem Cells ROCK H-1152 2HCl H-1152 Dihydrochloride H 1152 H 1152 dihydrochloride H1152 Dihydrochloride H 1152 Dihydrochloride H1152 dihydrochloride H1152 H-1152 Inhibitor inhibitor inhibit