PF-9184 is a potent and selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), IC50 =16.5 nM. PF-9184 inhibits IL-1β-induced PGE2 synthesis in vitro.
| パッケージサイズ | 在庫状況 | 単価(税別) | ||
|---|---|---|---|---|
| 無料サンプル 1 mg | ||||
| 1 mg | 在庫あり | ￥ 12000 | ||
| 2 mg | 在庫あり | ￥ 17500 | ||
| 5 mg | 在庫あり | ￥ 27000 | ||
| 100 mg | 在庫あり | お問い合わせ | ||
| 説明 | PF-9184 is a potent and selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), IC50 =16.5 nM. PF-9184 inhibits IL-1β-induced PGE2 synthesis in vitro. |
| In vitro | PF-9184 (0.015-100 μM; 24 hours) inhibits IL-1β-stimulated prostaglandin E2 (PGE2) synthesis in rheumatoid arthritis (RASF) in synovial fibroblasts derived from patients and has no apparent cytotoxic effects. PF-9184 (0.015-100 μM) potently blocks mPGES-1 ability to synthesize PGE2 from PGH2, and with no apparent inhibitory effects on COX-2 and prostacyclin synthase in cells. PF-9184 (0.015-100 μM) inhibits PGE2 weakly but has no effect on TXB2 synthesis except at 100 μM in human whole blood and modified blood assays. PF-9184 is a poor inhibitor of recombinant rat mPGES-1 (IC50=1080±398 nM)[1]. |
| In vivo | PF-9184 (oral administration or even local delivery) has no effect on PGE2 synthesis in recombinant rats[1]. |
| 別名 | PF9184, PF 9184 |
| 分子量 | 461.32 |
| 分子式 | C21H14Cl2N2O4S |
| CAS No. | 1221971-47-6 |
Powder: -20°C for 3 years In solvent: -80°C for 2 years
DMSO: 10 mg/mL (21.7 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
引用文献
投与量変換You can also refer to dose conversion for different animals. 詳細
In vivo投与量計算 (透明溶液)計算器bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
