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Trastuzumab deruxtecan (T-DXd) is an antibody-activated molecule coupling (ADC) with anticancer and antitumour activity.Trastuzumab deruxtecan has been shown to have an ameliorative effect in HER2-positive breast and gastric cancers.
説明 | Trastuzumab deruxtecan (T-DXd) is an antibody-activated molecule coupling (ADC) with anticancer and antitumour activity.Trastuzumab deruxtecan has been shown to have an ameliorative effect in HER2-positive breast and gastric cancers. |
ターゲット&IC50 | Axl(KPL-4 cells):109.7 pM |
In vitro | Trastuzumab deruxtecan, at concentrations ranging from 1 pM to 10 nM for 5 days (solution), inhibits the growth of HER2-positive KPL-4 cells, with an IC50 of 109.7 pM[4].Trastuzumab deruxtecan, at 10 nM for 5 days (solution), shows bystander killing effects in HER2-negative MDA-MB-468 cells[4]. |
In vivo | Trastuzumab deruxtecan (solution) at a single intravenous dose of 3 mg/kg exhibits antitumor activity against not only HER2-positive tumors but also HER2-negative tumors under the co-inoculated condition[4].Trastuzumab deruxtecan (solution) administered intravenously on days 0 and 7 at a dose of 10 mg/kg inhibits tumor growth in the EMT6-hHER2 syngeneic mouse model[3].Female BALB/c nude mice injected with NCI‐N87 and MDA‐MB‐468‐Luc cells[4] |
別名 | DS-8201a, VRN-101099, DS 8201, T-DXd |
分子量 | N/A |
分子式 | N/A |
CAS No. | 1826843-81-5 |
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You can also refer to dose conversion for different animals. 詳細
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Trastuzumab deruxtecan 1826843-81-5 Others DS-8201a VRN-101099 DS 8201 T-DXd Inhibitor inhibitor inhibit