Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UCM-1306 is a potent and orally active allosteric modulator (PAM) of human dopamine D1 receptor. UCM-1306 could increase the maximal effect of endogenous dopamine (DA) both in human and mouse D1 receptors. UCM-1306 could improve motor symptoms and address the key comorbid cognitive impairment associated with long-term Parkinson’s disease (PD).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 12,000 | |||
5 mg | 在庫あり | ¥ 28,000 | |||
10 mg | 在庫あり | ¥ 45,500 | |||
25 mg | 在庫あり | ¥ 91,000 | |||
50 mg | 在庫あり | ¥ 135,500 | |||
100 mg | 在庫あり | ¥ 193,500 |
説明 | UCM-1306 is a potent and orally active allosteric modulator (PAM) of human dopamine D1 receptor. UCM-1306 could increase the maximal effect of endogenous dopamine (DA) both in human and mouse D1 receptors. UCM-1306 could improve motor symptoms and address the key comorbid cognitive impairment associated with long-term Parkinson’s disease (PD). |
In vitro | UCM-1306 (1-10 μM) enhances CAMP in a concentration-response manner, EC50=60 nM[1]. |
In vivo | UCM-1306 (p.o.; C57BL/6J mice) has good brain penetration and oral availability. The plasma concentration can be quantified within 8 hours, and Tmax is 0.5 hours. UCM-1306 (1 mg/kg; ip) enhances cocaine induced hyperactivity in adult mice. UCM-1306 (1 mg/kg; ip) helps to consolidate the formation of long-term memory [1]. |
分子量 | 279.33 |
分子式 | C14H14FNO2S |
CAS No. | 2258608-78-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (161.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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UCM-1306 2258608-78-3 GPCR/G Protein Neuroscience Dopamine Receptor UCM 1306 UCM1306 UCM1036 Inhibitor inhibitor inhibit