Alkaloids are a class of naturally occurring organic compounds that mostly contain basic nitrogen atoms, produced by a large variety of organisms including bacteria, fungi, plants, and animals. Alkaloids have a wide range of pharmacological activities including antimalarial (e.g. quinine), antiasthma (e.g. ephedrine), anticancer (e.g. homoharringtonine), cholinomimetic (e.g. galantamine), vasodilatory (e.g. vincamine), antiarrhythmic (e.g. quinidine), analgesic (e.g. morphine), antibacterial (e.g. chelerythrine), and antihyperglycemic activities (e.g. piperine). Many have found use in traditional or modern medicine, or as starting points for drug discovery. Other alkaloids possess psychotropic (e.g. psilocin) and stimulant activities (e.g. cocaine, caffeine, nicotine, theobromine), and have been used in entheogenic rituals or as recreational drugs. Alkaloids can be toxic too (e.g. atropine, tubocurarine).
| カタログ番号 | 製品名 | ||
|---|---|---|---|
| T3029 | Sparteine sulfate | Sparteine sulfate is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium. | |
| T2S2104 | Sinigrin hydrate | 1. Sinigrin has antimicrobial activity. 2. Sinigrin exerts important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in rats, and highli... | |
| TN1012 | Febrifugine | Febrifugine is an effective coccidiostat, possesses schizonticide props; it and its derivatives shows high degree of antimalarial activity but use limited by tox... | |
| T4110 | Perivine | Perivine may resolve the instability of the retinoblastoma-associated proteins (RbAp48) complex and thus be used in Alzheimer's disease therapy. Perivine, vobasi... | |
| T4912 | Jatrorrhizine chloride | Jatrorrhizine chloride is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via in... | |
| T4S0083 | Protostemonine | 1. Protostemonine has anti-inflammatory activity, it effectively attenuates LPS-induced inflammatory responses in vitro and in vivo; the beneficial effects are a... | |
| TJS1226 | Aristolactam I | A natural compound from the herbs of Aristolochia debilis Sieb. et Zucc | |
| T36115 | Colchicoside | Colchicoside is extracted from Gloriosa superba and shows efficacy in a murine model of pancreatic adenocarcinoma. | |
| T8304 | Anisodamine Hydrobromide | Anisodamine Hydrobromide is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock. | |
| T8306 | Epiberberine chloride | Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07... | |
| T4183 | Lavendustin A | lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. | |
| TN7211 | Tetrahydroharmine | Tetrahydroharmine is a natural product found in the stems and large branches of Banisteriopsis caapi cultivar Da Vine. Tetrahydroharmine is a Monoamine oxidase A... | |
| T2173 | Veratridine | Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal. | |
| T1607 | Hydrastinine hydrochloride | Hydrastinine hydrochloride is a semisynthetic alkaloid from the hydrolysis of the alkaloid Hydrastine, used as a haemostatic drug. | |
| T2S0058 | 6-Ethoxychelerythrine | 6-Ethoxychelerythrine has anti-bacterial activity, it exhibited strong activity against Aspergillus fumigatus and methicillin-resistant Staphylococcus aureus (MR... | |
| T2782 | Catharanthine | Catharanthine suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM). | |
| T3S0804 | Worenine | Worenine is used in the a flurophore switched probe which aids in correction of an abasic site (AP site) caused by the removal of a damaged base in DNA. | |
| TCS2336 | Evodine | 1. Evodine has antinociceptive activity. | |
| TN2549 | 1-Methoxycarbonyl-β-carboline | 1-Methoxycarbonyl-β-carboline is an alkaloid from Ailanthus altissima. | |
| TN2460 | 12-Ethyl-9-hydroxycamptothecin | 7-Ethyl-10-Hydroxy-Camptothecin is a natural product isolated from Camptotheca acuminata Decne | |
| TCS2185 | Yohimbine | Yohimbine is a nonselective alpha 2-adrenergic receptor (AR) antagonist(IC50 : 0.6 μM) | |
| T3022 | Anhydrovinblastine | 3', 4'-Anhydrovinblastine is an antineoplastic agent. | |
| TN6787 | N-noratherosperminine | N-noratherosperminine is a alkaloid extract of the stem bark of Cryptocarya nigra. | |
| TN1139 | Dehydrocavidine | Dehydrocavidine has antitumor activity, it inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well ... | |
| T3S0626 | Denudatine | 1. Denudatine has effects on action potential of ventricular fibers and has inhibition on arrhythmogenic action of aconitine. | |
| TJS2216 | Aurantiamide acetate | Aurantiamide acetate was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally act... | |
| T3023 | Catharanthine sulfate | Catharanthine inhibits nicotinic receptor-mediated diaphragm contractions. | |
| T67708 | Thiolutin | Thiolutin is an inhibitor of endothelial cell adhesion and produced by Streptomyces. Thiolutin shows antibiotic and anti-angiogenic properties. Thiolutin induces... | |
| PDK0060 | Pseudotropine | Pseudotropine can cause hepatic necrosis and gastritis with ulceration or erosions. | |
| PDK0014 | 3-Methylxanthine | 3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.3-M... | |
| TN1012L | Febrifugine dihydrochloride | Febrifugine dihydrochloride is a biochemical with therapeutic activity regarding malaria, cancer, fibrosis and inflammatory diseases. | |
| TJS0123 | Guvacine ethyl ester | Arecoline is found in nuts. Arecoline is isolated from betel nuts Arecoline is an alkaloid natural product found in the areca nut, the fruit of the areca palm (A... | |
| TN2027 | Oxysanguinarine | Oxysanguinarine possesses antiplatelet aggregation activity, it has potential inhibitory properties against dengue virus. | |
| TN2298 | Vincosamide | Vincosamide is an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity. Vincosamide can ... | |
| T5784 | Topotecan | Topotecan is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases. | |
| TN2285 | DL-Tryptophan | Tryptophan containing dipeptides are interesting ingredients for functional foods as a natural prevention for hypertension with reduced side effects due to its s... | |
| TC0014 | Trachelanthine | Trachelanthine is a natural product from Eupatorium fortunei. | |
| TN3695 | Coniine hydrochloride | Coniine hydrochloride, a polyketide-derived alkaloid, is poisonous to humans and animals. It is a nicotinic acetylcholine receptor antagonist, which leads to inh... | |
| TN2213 | Imperialine 3-β-D-glucoside | Imperialine 3-β-D-glucoside is a natural product. Imperialine 3-β-D-glucoside may exhibit anti-tumor properties against multi-drug resistant tumor cells. | |
| Fr13711 | Tropinone | Tropinone used as an intermediate in the synthesis of atropine sulfate, and is a decane alkaloid. | |
| Fr16605 | Lupinine | Lupinine is an alkaloid capable of counteracting ethanol anesthesia. Lupinine is an AChE and BChE inhibitor and potential CD69 activator found in species of Lora... | |
| TN1754 | Hypaconine | Hypaconine is a C19-diterpenoid alkaloid isolated from Aconitum and Delphinium spp. It exhibits strong cardiac activity. | |
| TN1474 | Caulilexin C | Caulilexin C shows inhibitory activity on human Acyl CoA: cholesterol transferase I (hACATI) and on human Acyl CoA: cholesterol transferase 2 (hACAT2) at 100 mug... | |
| TC0022 | Desoxypeganine | Desoxypeganine is an inhibitor of cholinesterase. It acting preferentially on butyrylcholinesterase, and as a selective inhibitor of monoamine oxidase A but not ... | |
| TN1353 | N-Benzyllinoleamide | N-Benzyllinoleamide is a natural product isolated from Lepidium meyenii Walp, has pharmaceutical property against exercise-induced fatigue. | |
| Fr16741 | Oxindole | Oxindole is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure ... | |
| TC0039 | Vasicinone | Vasicinone may act as a hepatoprotective agent. (±)-Vasicinone has significant antitussive, expectorant, and bronchodilating activities, which can be used to tre... | |
| T5810 | TABERSONINE HYDROCHLORIDE | TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity. | |
| T0130 | Physostigmine Salicylate | Physostigmine, a parasympathomimetic alkaloid, is a reversible cholinesterase inhibitor. It extracts from the Calabar bean. | |
| T3002 | Piperine | Piperine (1-Piperoylpiperidine), a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders. |
