Cat. No. | 製品名 | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
T14997 | Conteltinib | 1384860-29-0 | 98% |
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Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK, and Pyk2.Conteltinib exhibits significant inhibition of FAK, overcomes hy... | ||||
T8152 | 6-Demethoxytangeretin | 6601-66-7 | 98% |
|
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. | ||||
T2641 | KRCA-0008 | 1472795-20-2 | 98% |
|
KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability. | ||||
T76858 | Ascrinvacumab | 1463459-96-2 | 98% |
Ascrinvacumab
|
Ascrinvacumab (PF-03446962) is a highly humanized IgG2 monoclonal antibody against ALK-1. Ascrinvacumab has a Kd value of 7 nM for human ALK1. Ascrinvacumab has ... | ||||
T5197 | BIBF0775 | 334951-90-5 | 98% |
|
BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM). | ||||
T35896 | AZ 12799734 | 1117684-36-2 | 98% |
|
AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours. | ||||
T4015 | HG-14-10-04 | 1356962-34-9 | 98% |
|
HG-14-10-04 is a potent and specific ALK inhibitor. | ||||
T35694 | OD36 | 1638644-62-8 | 98% |
|
OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficien... | ||||
T77726 | INCB-000928 | 2173389-57-4 | 98% |
|
Zilurgisertib (INCB-000928) is a selective and potent ALK 2 inhibitor for the study of cancer and MF anemia. | ||||
T1936 | Alectinib | 1256580-46-7 | 98% |
|
Alectinib (RG-7853) is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. | ||||
T50042 | 5-phenylthieno[2,3-d]pyrimidin-4-amine | 195193-10-3 |
|
|
5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocyclic compound. It inhibits a variety of enzymes such as kinases and phosphodiesterases and has potential ther... | ||||
T2612 | CEP-28122 | 1022958-60-6 |
|
|
CEP-28122 is a highly potent and selective orally active ALK inhibitor. | ||||
T3031 | A 83-01 | 909910-43-6 |
|
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A 83-01 (ALK5 Inhibitor IV) is an inhibitor of the TGF-β type I receptors ALK5, ALK4, and ALK7 (IC50=12/45/7.5 nM). A 83-01 promotes the reprogramming of mouse f... | ||||
T6158 | LDN-193189 HCl | 1062368-62-0 | 100% |
|
LDN-193189 HCl (LDN193189 Hydrochloride) is a selective BMP type I receptor kinases inhibitor. | ||||
T3621 | Brigatinib | 1197953-54-0 | 100% |
|
Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor. | ||||
T13564 | AZ7550 | 1421373-99-0 | 97.07% |
|
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM). | ||||
T11254 | F-1 | 2244775-31-1 | 97.66% |
|
F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppress... | ||||
T3059 | ALK-IN-1 | 1197958-12-5 | 97.66% |
|
ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M ... | ||||
T1962 | ASP3026 | 1097917-15-1 | 98% |
|
ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Posit... | ||||
T1800 | GW788388 | 452342-67-5 | 98% |
|
GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities. |