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Akt

Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T14034 3CAI 28755-03-5 98%
3CAI is a potent and specific AKT1 and AKT2 inhibitor which showed significant inhibition of AKT in an in vitro kinase assay and suppressed expression of AKT dir...
T6252 Ipatasertib 1001264-89-6 98%
Ipatasertib (GDC-0068), a highly specific pan-Akt inhibitor, targets Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, respectively.
T3P2904 α-Linolenic acid 463-40-1 98%
Linolenic Acid is an essential fatty acid belonging to the omega-3 fatty acids group. It is highly concentrated in certain plant oils and has been reported to in...
T0228 Methyl-Hesperidin 11013-97-1 98%
Methyl Hesperidin, a flavanone glycoside (flavonoid) (C28H34O15), is abundant in citrus fruits. Its aglycone form is called hesperetin.
T2S1040 Jolkinolide B 37905-08-1 98%
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
T4046 BX517 850717-64-5 98%
BX-517 is a potent and selective inhibitor of PDK1.
T14072 A-443654 552325-16-3 98%
A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T4489 AKT-IN-1 1357158-81-6 98%
AZD-26 is an allosteric AKT inhibitor (IC50: 1.04 μM).
T15469 Hematein 475-25-2 98%
Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxy...
T9831 MKC-1 125313-92-0 98%
MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhib...
T5S0168 Atractylenolide II 73069-14-4 98%
1. Atractylenolide II has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation , ERK ...
T15374 Ipatasertib dihydrochloride 1396257-94-5 98%
Ipatasertib dihydrochloride is a highly selective and ATP-competitive inhibitor of pan-Akt (IC50s: 5, 18, and 8 nM for Akt1, Akt2, and Akt3, respectively).
T4444 A-674563 HCl (552325-73-2(free base)) 98%
A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 ...
T3132 SC66 871361-88-5 98%
SC66 is a AKT inhibitor in HepG2, HA22T/VGH, and PLC/PRF/5 cells (IC50: about 0.75 μg/ml, at 72 h).
TN2063 Physalin B 23133-56-4 98%
Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammat...
T23695 Akt-I-1,2 473382-50-2 98%
Akt-I-1,2 is a selective inhibitor of Akt1 and Akt2.
T2895 Lupeol 545-47-1 98%
Lupeol is a novel androgen receptor inhibitor with anti-inflammatory and antioxidant activity.
T6303 CCT128930 885499-61-6 98%
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinas...
T0392 Artemisinin 63968-64-9 98%
Artemisinin is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organis...
T25017 AKT-I-1 473382-39-7 98%
AKT-I-1 is a selective and reversible inhibitor of Akt1.
3CAI
T14034
3CAI is a potent and specific AKT1 and AKT2 inhibitor which showed significant inhibition of AKT in an in vitro kinase assay and suppressed expression of AKT dir...
Ipatasertib
T6252
Ipatasertib (GDC-0068), a highly specific pan-Akt inhibitor, targets Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, respectively.
α-Linolenic acid
T3P2904
Linolenic Acid is an essential fatty acid belonging to the omega-3 fatty acids group. It is highly concentrated in certain plant oils and has been reported to in...
Methyl-Hesperidin
T0228
Methyl Hesperidin, a flavanone glycoside (flavonoid) (C28H34O15), is abundant in citrus fruits. Its aglycone form is called hesperetin.
Jolkinolide B
T2S1040
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
BX517
T4046
BX-517 is a potent and selective inhibitor of PDK1.
A-443654
T14072
A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
AKT-IN-1
T4489
AZD-26 is an allosteric AKT inhibitor (IC50: 1.04 μM).
Hematein
T15469
Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxy...
MKC-1
T9831
MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhib...
Atractylenolide II
T5S0168
1. Atractylenolide II has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation , ERK ...
Ipatasertib dihydrochloride
T15374
Ipatasertib dihydrochloride is a highly selective and ATP-competitive inhibitor of pan-Akt (IC50s: 5, 18, and 8 nM for Akt1, Akt2, and Akt3, respectively).
A-674563 HCl (552325-73-2(free base))
T4444
A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 ...
SC66
T3132
SC66 is a AKT inhibitor in HepG2, HA22T/VGH, and PLC/PRF/5 cells (IC50: about 0.75 μg/ml, at 72 h).
Physalin B
TN2063
Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammat...
Akt-I-1,2
T23695
Akt-I-1,2 is a selective inhibitor of Akt1 and Akt2.
Lupeol
T2895
Lupeol is a novel androgen receptor inhibitor with anti-inflammatory and antioxidant activity.
CCT128930
T6303
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinas...
Artemisinin
T0392
Artemisinin is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organis...
AKT-I-1
T25017
AKT-I-1 is a selective and reversible inhibitor of Akt1.
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