| T14034 |
3CAI
|
28755-03-5
|
98%
|
|
|
3CAI is a potent and specific AKT1 and AKT2 inhibitor which showed significant inhibition of AKT in an in vitro kinase assay and suppressed expression of AKT dir...
|
| T2S1040 |
Jolkinolide B
|
37905-08-1
|
98%
|
|
|
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
|
| T4046 |
BX517
|
850717-64-5
|
98%
|
|
|
BX517 (PDK1 inhibitor 2) is a potent and selective inhibitor of PDK1.
|
| T15469 |
Hematein
|
475-25-2
|
98%
|
|
|
Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxy...
|
| T15374 |
Ipatasertib dihydrochloride
|
1396257-94-5
|
98%
|
|
|
Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive inhibitor of pan-Akt (IC50s: 5, 18 and 8 nM for Akt1, Akt2 and A...
|
| T76796 |
Patritumab
|
1262787-83-6
|
98%
|
|
|
Patritumab (U3-1287) is an anti-HER3 monoclonal antibody with potential antitumor activity and inhibits phosphorylation of EGFR, HER2, HER3, ERK, and AKT.Patritu...
|
| T23695 |
Akt-I-1,2
|
473382-50-2
|
98%
|
|
|
Akt-I-1,2 is a selective inhibitor of Akt1 and Akt2.
|
| T25017 |
AKT-I-1
|
473382-39-7
|
98%
|
|
|
AKT-I-1 is a selective and reversible inhibitor of Akt1.
|
| T14072 |
A-443654
|
552325-16-3
|
|
|
|
A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
|
| T3399 |
Psoralidin
|
18642-23-4
|
|
|
|
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
|
| T7315 |
BAY1125976
|
1402608-02-9
|
|
|
|
BAY1125976 is an allosteric inhibitor of Akt1 and Akt2 (IC50s of 5.2 and 18 nM, respectively, in a time-resolved FRET assay)
|
| T7190 |
Actein
|
18642-44-9
|
|
|
|
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblast...
|
| T3S0209 |
Vincristine
|
57-22-7
|
100%
|
|
|
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...
|
| T6065 |
Triciribine
|
35943-35-2
|
100%
|
|
|
Triciribine (NSC-154020) is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.
|
| T7879 |
TASP0415914
|
1292300-75-4
|
100%
|
|
|
TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T
|
| T7885 |
Afuresertib hydrochloride
|
1047645-82-8
|
100%
|
|
|
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
|
| T9393 |
(E)-Akt inhibitor-IV
|
959841-49-7
|
100.00%
|
|
|
(E)-Akt inhibitor-IV ((E)-AKTIV) ((E)-AKTIV) is an inhibitor of PI3K-Akt.
|
| T76795 |
Xentuzumab
|
1417158-65-6
|
95.21%
|
|
|
Xentuzumab (BI836845) is a recombinant monoclonal antibody to humanised IGF ligand that inhibits IGF1 and IGF2 growth-promoting signalling and inhibits AKT activ...
|
| TN1405 |
Arnicolide D
|
34532-68-8
|
96.66%
|
|
|
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
|
| T25150 |
BI-69A11
|
1233322-09-2
|
96.97%
|
|
|
BI-69A11 ((E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one) is a dual AKT and NFkB pathway inhibitor. It enhances the...
|
