| T14034 |
3CAI
|
28755-03-5
|
98%
|
|
|
3CAI is a potent and specific AKT1 and AKT2 inhibitor which showed significant inhibition of AKT in an in vitro kinase assay and suppressed expression of AKT dir...
|
| T3P2904 |
α-Linolenic acid
|
463-40-1
|
98%
|
|
|
α-Linolenic acid (Alpha-Linolenic Acid) is an essential fatty acid belonging to the omega-3 fatty acids group. It is highly concentrated in certain plant oils an...
|
| T1920 |
Capivasertib
|
1143532-39-1
|
98%
|
|
|
Capivasertib (AZD5363) is a broad-spectrum AKT inhibitor with inhibitory activity against Akt1, Akt2, and Akt3 (IC50=3/7/7 nM) with oral activity. Capivasertib h...
|
| T3895 |
Polyphyllin I
|
50773-41-6
|
98%
|
|
|
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, c...
|
| T2S1040 |
Jolkinolide B
|
37905-08-1
|
98%
|
|
|
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
|
| T4046 |
BX517
|
850717-64-5
|
98%
|
|
|
BX517 (PDK1 inhibitor 2) is a potent and selective inhibitor of PDK1.
|
| T14072 |
A-443654
|
552325-16-3
|
98%
|
|
|
A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
|
| T15469 |
Hematein
|
475-25-2
|
98%
|
|
|
Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxy...
|
| T5S0168 |
Atractylenolide II
|
73069-14-4
|
98%
|
|
|
1. Atractylenolide II (2-Atractylenolide) has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p...
|
| T3399 |
Psoralidin
|
18642-23-4
|
98%
|
|
|
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
|
| T15374 |
Ipatasertib dihydrochloride
|
1396257-94-5
|
98%
|
|
|
Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive inhibitor of pan-Akt (IC50s: 5, 18 and 8 nM for Akt1, Akt2 and A...
|
| T4444 |
A-674563 HCl (552325-73-2(free base))
|
2070009-66-2
|
98%
|
|
|
A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 ...
|
| T76796 |
Patritumab
|
1262787-83-6
|
98%
|
|
|
Patritumab (U3-1287) is an anti-HER3 monoclonal antibody with potential antitumor activity and inhibits phosphorylation of EGFR, HER2, HER3, ERK, and AKT.Patritu...
|
| T76795 |
Xentuzumab
|
1417158-65-6
|
98%
|
|
|
Xentuzumab (BI836845) is a recombinant monoclonal antibody to humanised IGF ligand that inhibits IGF1 and IGF2 growth-promoting signalling and inhibits AKT activ...
|
| T23695 |
Akt-I-1,2
|
473382-50-2
|
98%
|
|
|
Akt-I-1,2 is a selective inhibitor of Akt1 and Akt2.
|
| T6849 |
Uprosertib
|
1047634-65-0
|
98%
|
|
|
Uprosertib (GSK2141795) (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 a...
|
| T25017 |
AKT-I-1
|
473382-39-7
|
98%
|
|
|
AKT-I-1 is a selective and reversible inhibitor of Akt1.
|
| T6S0525 |
Farrerol
|
24211-30-1
|
98%
|
|
|
1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection an...
|
| T13862 |
Recilisib
|
334969-03-8
|
|
|
|
Recilisib (ON 01210) is a radioprotectant,can activate AKT, PI3K activities in cells.
|
| T7315 |
BAY1125976
|
1402608-02-9
|
|
|
|
BAY1125976 is an allosteric inhibitor of Akt1 and Akt2 (IC50s of 5.2 and 18 nM, respectively, in a time-resolved FRET assay)
|
