| T26193 |
SKLB-163
|
1255099-06-9
|
98.31%
|
|
|
SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.
|
| T11961 |
MBM-55S
|
2083624-07-9
|
98.38%
|
|
|
MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer ce...
|
| TN2063 |
Physalin B
|
23133-56-4
|
98.40%
|
|
|
Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammat...
|
| T5S0506 |
Rotundic acid
|
20137-37-5
|
98.43%
|
|
|
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (N...
|
| T0228 |
Methyl-Hesperidin
|
11013-97-1
|
98.51%
|
|
|
Methyl Hesperidin, a flavanone glycoside (flavonoid) (C28H34O15), is abundant in citrus fruits. Its aglycone form is called hesperetin.
|
| T6303L |
CCT128930 hydrochloride
|
2453324-32-6
|
98.55%
|
|
|
CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest...
|
| T6251 |
PF-04691502
|
1013101-36-4
|
98.63%
|
|
|
PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.
|
| T19094 |
2,3-Butanediol
|
513-85-9
|
98.64%
|
|
|
2,3-Butanediol is a butanediol derived from the bioconversion of natural resources which has great potential for diverse industries, including chemical, cosmetic...
|
| T5736 |
1,3-Dicaffeoylquinic acid
|
19870-46-3
|
98.68%
|
|
|
1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
|
| T3346 |
AKT inhibitor VIII
|
612847-09-3
|
98.77%
|
|
|
AKT inhibitor VIII (AKTi-1/2) is a highly specific Akt1/2 inhibitor (IC50: 58/210 nM). The selectivity for Akt1 is higher about 36-fold than Akt3.
|
| T6285 |
GSK-690693
|
937174-76-0
|
98.78%
|
|
|
GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
|
| T36310 |
AKT-IN-6
|
1430056-54-4
|
98.83%
|
|
|
AKT-IN-6 (INCB-047775) has an inhibitory effect on ATK. Akt is an important component of cellular signaling for growth factors, cytokines, and other cell stimuli...
|
| T10276L |
AKT Kinase Inhibitor HCl
|
|
98.87%
|
|
|
AKT Kinase Inhibitor HCl is an Akt inhibitor with antitumor activity.
|
| T39988 |
6'-GNTI dihydrochloride
|
2410327-94-3
|
98.91%
|
|
|
6'-GNTI dihydrochloride is a κ-opioid receptor (KOR) agonist that favors activation of G-protein-mediated signaling over recruitment of β-aspirin 2. 6'-GNTI dihy...
|
| TN1990 |
Norathyriol
|
3542-72-1
|
98.93%
|
|
|
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
|
| T2482 |
AT13148
|
1056901-62-2
|
99%
|
|
|
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
|
| T6252 |
Ipatasertib
|
1001264-89-6
|
99.03%
|
|
|
Ipatasertib (GDC-0068) (GDC-0068), a highly specific pan-Akt inhibitor, targets Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, respectively.
|
| T2790 |
Oridonin
|
28957-04-2
|
99.04%
|
|
|
Oridonin (NSC-250682) is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of...
|
| T8969 |
API-1
|
36707-00-3
|
99.07%
|
|
|
API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .
|
| T3826 |
Polygalasaponin F
|
882664-74-6
|
99.15%
|
|
|
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and re...
|
