TN1990 |
Norathyriol
|
3542-72-1
|
98.93%
|
|
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
|
T2482 |
AT13148
|
1056901-62-2
|
99%
|
|
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
|
T6252 |
Ipatasertib
|
1001264-89-6
|
99.03%
|
|
Ipatasertib (GDC-0068) (GDC-0068), a highly specific pan-Akt inhibitor, targets Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, respectively.
|
T2790 |
Oridonin
|
28957-04-2
|
99.04%
|
|
Oridonin (NSC-250682) is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of...
|
T8969 |
API-1
|
36707-00-3
|
99.07%
|
|
API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .
|
T3826 |
Polygalasaponin F
|
882664-74-6
|
99.15%
|
|
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and re...
|
TN1433 |
Batatasin III
|
56684-87-8
|
99.16%
|
|
Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities...
|
T2S2215 |
Crebanine
|
25127-29-1
|
99.17%
|
|
1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ...
|
T6303 |
CCT128930
|
885499-61-6
|
99.18%
|
|
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinas...
|
T6139 |
A-674563
|
552325-73-2
|
99.21%
|
|
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
|
T24398 |
Lenaldekar
|
418800-15-4
|
99.25%
|
|
Lenaldekar (LDK) inhibits T-cell expansion and autoimmune encephalomyelitis. Lenaldekar causes dephosphorylation of members of the PI3 kinase/AKT/mTOR pathway an...
|
T2895 |
Lupeol
|
545-47-1
|
99.31%
|
|
Lupeol (Monogynol B) is a novel androgen receptor inhibitor with anti-inflammatory and antioxidant activity.
|
T2789 |
Scutellarin
|
27740-01-8
|
99.32%
|
|
Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in...
|
T2746 |
Sophocarpine monohydrate
|
145572-44-7
|
99.33%
|
|
Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
|
TN1911 |
Marein
|
535-96-6
|
99.34%
|
|
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation o...
|
T3P2904 |
α-Linolenic acid
|
463-40-1
|
99.36%
|
|
α-Linolenic acid (Alpha-Linolenic Acid) is an essential fatty acid belonging to the omega-3 fatty acids group. It is highly concentrated in certain plant oils an...
|
T3895 |
Polyphyllin I
|
50773-41-6
|
99.36%
|
|
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, c...
|
T11928 |
M2698
|
1379545-95-5
|
99.36%
|
|
M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity.
|
T13376 |
YS-49
|
132836-42-1
|
99.42%
|
|
YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).
|
T5S1331 |
Herbacetin
|
527-95-7
|
99.51%
|
|
1. Herbacetin induces apoptosis in HepG2 cells, by ROS and PI3K/Akt pathway. 2. Herbacetin suppresses the HGF-induced motility of human breast cancer MDA-MB-231 ...
|