| TN1472 |
Cassiaside
|
13709-03-0
|
98%
|
|
|
Cassiaside is a naphthyl ketone glycoside that inhibits BACE1 (IC50= 4.45 μM; Ki=9.85 μM).Cassiaside exhibits significant hepatoprotective effects against galact...
|
| T7011 |
Verubecestat
|
1286770-55-5
|
98%
|
|
|
Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
|
| T83616 |
SEW06622
|
261349-28-4
|
98%
|
|
|
SEW06622 is a potent inhibitor of acetylcholinesterase (AChE) and beta-secretase-1 (BACE-1) and is a potential candidate for the treatment of Alzheimer's disease...
|
| T2759 |
Loganin
|
18524-94-2
|
100%
|
|
|
Loganin (Loganoside), an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has disp...
|
| T13253 |
Umibecestat
|
1387560-01-1
|
100%
|
|
|
Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, r...
|
| T3161L |
BACE-IN-1 acetate
|
|
96.98%
|
|
|
BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4，Free base)) has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE...
|
| T4115 |
Auraptene
|
495-02-3
|
98%
|
|
|
Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuro...
|
| T5S2361 |
Epiberberine
|
6873-09-2
|
98.95%
|
|
|
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/...
|
| T2639 |
LY2811376
|
1194044-20-6
|
99.01%
|
|
|
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity...
|
| TN2190 |
Scoulerine
|
6451-73-6
|
99.22%
|
|
|
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, ar...
|
| T12188 |
NB-360
|
1262857-73-7
|
99.25%
|
|
|
NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent ...
|
| T61439 |
DSS30
|
883027-32-5
|
99.61%
|
|
|
DSS30 is a P25/CDK5 inhibitor.DSS30 acts by inhibiting the phosphorylation of amyloid precursor protein cleaving enzyme 1 (BACEl), which reduces the secretion of...
|
| T11175 |
Elenbecestat
|
1388651-30-6
|
99.67%
|
|
|
Elenbecestat (E2609) is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease.
|
| TN1799 |
Isorubrofusarin-6-O-β-gentiobioside
|
200127-93-1
|
99.69%
|
|
|
Isorubrofusarin-6-O-β-gentiobioside is derived from from Cassia obtusifolia Linn seeds and shows promising inhibitory activity against AChE and BACE1.
|
| T3394 |
Timosaponin BII
|
136656-07-0
|
99.77%
|
|
|
Timosaponin BII (Prototimosaponin A III) has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activ...
|
| T8179 |
Aloeresin D
|
105317-67-7
|
99.84%
|
|
|
Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).
|
| TN1343 |
8-Geranyloxypsoralen
|
7437-55-0
|
99.87%
|
|
|
8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arter...
|
| T4398 |
LX2343
|
333745-53-2
|
99.92%
|
|
|
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343...
|
| T6772 |
AZD3839 free base
|
1227163-84-9
|
99.93%
|
|
|
AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
|
| T6058 |
LY2886721
|
1262036-50-9
|
99.94%
|
|
|
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
|
