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BCL

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T7727 Se-Methylselenocysteine 26046-90-2 98%
Se-Methylselenocysteine is a drug potentially for the treatment of solid tumors. Se-Methylselenocysteine exerts pro-apoptosis effects through increasing Cx43 exp...
TN2019 Orobol 480-23-9 98%
Orobol is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α...
T0186 Docetaxel trihydrate 148408-66-6 98%
Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the the...
T2S1040 Jolkinolide B 37905-08-1 98%
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
T6778 BDA-366 1909226-00-1 98%
BDA-366 is a potent Bcl2 antagonist, binding Bcl2-BH4 domain with high affinity and selectivity (Ki = 3.3 nM). BDA-366 induces conformational change in Bcl2 that...
T1119 Rasagiline 136236-51-6 98%
Rasagiline is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons disease.
T5S0993 Kurarinone 34981-26-5 98%
Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
TN3967 Epieriocalyxin A 191545-24-1 98%
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth, it could be a potential drug for colon cancer therapy in the future.
T6034 UMI-77 518303-20-3 98%
UMI-77, a specific Mcl-1 inhibitor (Ki: 490 nM), has selectivity over other members of Bcl-2 family.
TN1195 17-Hydroxy sprengerinin C 1029017-75-1 98%
17-Hydroxy sprengerinin C is a glycoside compound isolated from rhizomes of Polygonatum sibiricum with stronger anticancer activities. 17-Hydroxy sprengerinin C ...
T77571 Bcl-B inhibitor 1 79220-88-5 98%
Bcl-B inhibitor 1 is a Bcl-B inhibitor with antitumor activity that binds to and inactivates pro-apoptotic proteins in the BH3 structural domain.
T5408 BI-3802 2166387-65-9 98%
BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 value of ≤3 nM. BI-3802 induces the polymerization of BCL...
T25049 Allethrin 584-79-2 98%
The allethrins are a group of related synthetic compounds utilized in insecticides.
T37518 Diphenyl disulfide 882-33-7 98%
Diphenyl disulfide shows anticancer activity in breast cancer cell lines.Diphenyl disulfide induces and enhances apoptosis in breast cancer cells through Bax pro...
TN2063 Physalin B 23133-56-4 98%
Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammat...
T2632 A-1210477 1668553-26-1 98%
A-1210477 is an effective and specific MCL-1 and Bcl-2 inhibitor (Ki/IC50: 0.454/26.2 nM).
T3344 Ciwujianoside B 114902-16-8 98%
Ciwujianoside-B is the main component of Acanthopanax, can relieve fatigue, enhance memory, and improve human cognition.
TN4583 Moringin 73255-40-0 98%
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
T9083 TC11 100823-03-8 98%
TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.
T3940 CID5721353 301356-95-6 98%
CID5721353 is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor) that disrupts BCL6/corepressor complexes in vitro and in vivo, and was shown to bind the critical si...
Se-Methylselenocysteine
T7727
Se-Methylselenocysteine is a drug potentially for the treatment of solid tumors. Se-Methylselenocysteine exerts pro-apoptosis effects through increasing Cx43 exp...
Orobol
TN2019
Orobol is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α...
Docetaxel trihydrate
T0186
Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the the...
Jolkinolide B
T2S1040
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
BDA-366
T6778
BDA-366 is a potent Bcl2 antagonist, binding Bcl2-BH4 domain with high affinity and selectivity (Ki = 3.3 nM). BDA-366 induces conformational change in Bcl2 that...
Rasagiline
T1119
Rasagiline is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons disease.
Kurarinone
T5S0993
Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
Epieriocalyxin A
TN3967
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth, it could be a potential drug for colon cancer therapy in the future.
UMI-77
T6034
UMI-77, a specific Mcl-1 inhibitor (Ki: 490 nM), has selectivity over other members of Bcl-2 family.
17-Hydroxy sprengerinin C
TN1195
17-Hydroxy sprengerinin C is a glycoside compound isolated from rhizomes of Polygonatum sibiricum with stronger anticancer activities. 17-Hydroxy sprengerinin C ...
Bcl-B inhibitor 1
T77571
Bcl-B inhibitor 1 is a Bcl-B inhibitor with antitumor activity that binds to and inactivates pro-apoptotic proteins in the BH3 structural domain.
BI-3802
T5408
BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 value of ≤3 nM. BI-3802 induces the polymerization of BCL...
Allethrin
T25049
The allethrins are a group of related synthetic compounds utilized in insecticides.
Diphenyl disulfide
T37518
Diphenyl disulfide shows anticancer activity in breast cancer cell lines.Diphenyl disulfide induces and enhances apoptosis in breast cancer cells through Bax pro...
Physalin B
TN2063
Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammat...
A-1210477
T2632
A-1210477 is an effective and specific MCL-1 and Bcl-2 inhibitor (Ki/IC50: 0.454/26.2 nM).
Ciwujianoside B
T3344
Ciwujianoside-B is the main component of Acanthopanax, can relieve fatigue, enhance memory, and improve human cognition.
Moringin
TN4583
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
TC11
T9083
TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.
CID5721353
T3940
CID5721353 is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor) that disrupts BCL6/corepressor complexes in vitro and in vivo, and was shown to bind the critical si...
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