| T14071 |
A-385358
|
406228-55-5
|
97.40%
|
|
|
A-385358 is a selective Bcl-xL inhibitor with Kis of 0.80 nM for Bcl-xL and 67 nM for Bcl-2, respectively.
|
| T11944 |
Maritoclax
|
1227962-62-0
|
97.70%
|
|
|
Maritoclax (Marinopyrrole A) (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor, shows >8 fold selectivity than BCL-xl (IC50 > 80 μM),with an IC50 value o...
|
| T77571 |
Bcl-B inhibitor 1
|
79220-88-5
|
97.77%
|
|
|
Bcl-B inhibitor 1 is a Bcl-B inhibitor with antitumor activity that binds to and inactivates pro-apoptotic proteins in the BH3 structural domain.
|
| T5679 |
(E)-Ferulic acid
|
537-98-4
|
98%
|
|
|
(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of ...
|
| T1980 |
HA14-1
|
65673-63-4
|
98%
|
|
|
HA14-1, a Bcl-2/Bcl-XL antagonist, is a non-peptidic ligand of a Bcl-2 surface pocket (IC50: ~9 μM).
|
| T6748 |
A-1155463
|
1235034-55-5
|
98%
|
|
|
A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related protein...
|
| T6281 |
TW-37
|
877877-35-5
|
98%
|
|
|
TW-37 is an nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 (Ki: 0.29/1.11/0.26 μM).
|
| T5668 |
Triacetylresveratrol
|
42206-94-0
|
98%
|
|
|
Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulate...
|
| T16028 |
IMB-XH1
|
292057-76-2
|
98%
|
|
|
IMB-XH1 (Mcl1-IN-2) is a myeloid cell factor 1 (Mcl-1) inhibitor.
|
| T17018 |
TCPOBOP
|
76150-91-9
|
98.08%
|
|
|
TCPOBOP is a constitutive androstane receptor agonist that induces robust hepatocyte proliferation and hepatomegaly. TCPOBOP decreases Fas-induced murine liver i...
|
| T9083 |
TC11
|
100823-03-8
|
98.1%
|
|
|
TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis vi...
|
| T6749 |
A-1331852
|
1430844-80-6
|
98.15%
|
|
|
A-1331852 is a potent and selectiveBCL-XL inhibitor and may be useful in the treatment of cancer, immune and autoimmune diseases.
|
| T4089 |
FX1
|
1426138-42-2
|
98.15%
|
|
|
FX1 is an effective and selective BCL6 inhibitor (IC50: 35 μM).
|
| T1493 |
BH3I-1
|
300817-68-9
|
98.2%
|
|
|
BH3I-1 (BHI1) is a Bcl-2 antagonist.
|
| T3864 |
Erianin
|
95041-90-0
|
98.22%
|
|
|
Erianin is a nature product extracted from Dendrobium chrysotoxum, has notable antitumour activity , can cause extensive tumour necrosis, growth delay. Erianin h...
|
| T5S2358 |
Dehydrocorydaline
|
30045-16-0
|
98.36%
|
|
|
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stim...
|
| T6185 |
Gambogic Acid
|
2752-65-0
|
98.38%
|
|
|
Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC5...
|
| T6650 |
Sabutoclax
|
1228108-65-3
|
98.5%
|
|
|
Sabutoclax (BI-97C1)(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively...
|
| T5346 |
S63845
|
1799633-27-4
|
98.56%
|
|
|
S63845 is a selective MCL-1 inhibitor(Kd: 0.19 nM)
|
| T2730 |
Gossypol (acetic acid)
|
12542-36-8
|
98.57%
|
|
|
Gossypol acetic acid (AT101), a polyphenolic compound isolated from cottonseeds, binds with Bcl-2, Bcl-xL, Mcl-1, and does not inhibit BIR3 domain and BID.
|
