T4089 |
FX1
|
1426138-42-2
|
98.15%
|
|
FX1 is an effective and selective BCL6 inhibitor (IC50: 35 μM).
|
T1493 |
BH3I-1
|
300817-68-9
|
98.2%
|
|
BH3I-1 (BHI1) is a Bcl-2 antagonist.
|
T5S2358 |
Dehydrocorydaline
|
30045-16-0
|
98.36%
|
|
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stim...
|
T6185 |
Gambogic Acid
|
2752-65-0
|
98.38%
|
|
Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC5...
|
T6650 |
Sabutoclax
|
1228108-65-3
|
98.5%
|
|
Sabutoclax (BI-97C1)(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively...
|
T2730 |
Gossypol (acetic acid)
|
12542-36-8
|
98.57%
|
|
Gossypol acetic acid (AT101), a polyphenolic compound isolated from cottonseeds, binds with Bcl-2, Bcl-xL, Mcl-1, and does not inhibit BIR3 domain and BID.
|
T4S0181 |
Hinokiflavone
|
19202-36-9
|
98.67%
|
|
Hinokiflavone is a novel modulator of pre-mRNA splicing activity in vitro and in cellulo. Hinokiflavone blocks splicing of pre-mRNA substrates by inhibiting spli...
|
T1901 |
(E/Z)-TG003
|
300801-52-9
|
98.73%
|
|
(E/Z)-TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor.
|
T3419 |
Chelerythrine chloride
|
3895-92-9
|
98.78%
|
|
Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ...
|
T6S0052 |
Chelerythrine
|
34316-15-9
|
98.86%
|
|
1. Chelerythrine (Broussonpapyrine) may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase...
|
T4088 |
Thymoquinone
|
490-91-5
|
98.98%
|
|
Thymoquinone (NSC 2228) is a compound be found in herbs and spices with anti-inflammatory and anti-oxidant effects.
|
T12824L |
S55746
|
1448584-12-0
|
98.99%
|
|
S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).
|
T6881 |
LTX-315
|
1345407-05-7
|
99%
|
|
LTX-315 (Oncopore), the oncolytic peptide, inhibits cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.
|
T12186 |
Navitoclax-piperazine
|
2143096-93-7
|
99.11%
|
|
Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL).
|
T1119 |
Rasagiline
|
136236-51-6
|
99.14%
|
|
Rasagiline (AGN1135) is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons di...
|
T5104 |
BTSA1
|
314761-14-3
|
99.15%
|
|
BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX...
|
TN1891 |
Lupiwighteone
|
104691-86-3
|
99.20%
|
|
Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
|
T2101 |
Navitoclax
|
923564-51-6
|
99.22%
|
|
Navitoclax (ABT-263) (ABT-263) is a potent, orally bioavailable Bcl-2 family protein inhibitor that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki < 1 nM for all thre...
|
T2453 |
BAM7
|
331244-89-4
|
99.23%
|
|
BAM 7 is a direct and specific activator of proapoptotic Bax (EC50: 3.3 μM).
|
T38622 |
Bcl-xL antagonist 2
|
1235032-75-3
|
99.26%
|
|
Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer c...
|