ペプチド
抗体
色素試薬
PROTAC
バーチャルスクリーニング
Targetmolキット
Cell Counting Kit-8 (CCK-8)
Inhibitor Cocktails
天然化合物
フェノール類
アルカロイド類
フラボノイド類
阻害剤
血管新生
アポトーシス
オートファジー
細胞周期・チェックポイント
クロマチン・エピジェネティック
細胞骨格シグナル
DNA損傷・DNA修復
内分泌・ホルモン
GPCR/Gタンパク質
免疫・炎症
JAK・STATシグナル
| Cat. No. | 製品名 | CAS No. | Purity | Chemical Structure |
|---|---|---|---|---|
| T12907 | SIAIS178 | 2376047-73-1 | 98% |
|
| SIAIS178 is a potent and selective degrader of BCR-ABL based on PROTAC technology (IC50 of 24 nM). | ||||
| T10488 | BCR-ABL-IN-1 | 188260-50-6 | 98% |
|
| BCR-ABL-IN-1 is a BCR-ABL tyrosine kinase inhibitor (pIC50: 6.46) and may be used in the research of chronic myelogenous leukemia. | ||||
| T22378 | Nilotinib hydrochloride | 923288-95-3 | 98% |
|
| Nilotinib hydrochloride, the hydrochloride salt form of nilotinib, is an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. | ||||
| T6650 | Sabutoclax | 1228108-65-3 | 98% |
|
| Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively. | ||||
| T14925 | Cenisertib | 871357-89-0 | 98% |
|
| Cenisertib is A potent ATP-competitive multi-kinase inhibitor, showing inhibitory effects on the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5, FLT3, as well a... | ||||
| T10583 | Bosutinib D8 | T10583 | 98% |
|
| Bosutinib D8 is a deuterium-labeled Bosutinib. Bosutinib (SKI-606) is a dual Src/Abl inhibitor (IC50s: 1.2 nM/1 nM). | ||||
| T28374 | PF-06651481-00 | 1391063-17-4 | 98% |
|
| PF-06651481-00 is a Bosutinib analog and a Bcr-Abl inhibitor. | ||||
| T16545 | Pivanex | 122110-53-6 | 98% |
|
| Pivanex is a derivative of Butyric acid and is an orally active HDAC inhibitor. Pivanex has antimetastic and antiangiogenic properties. Pivanex down-regulates bc... | ||||
| T7186 | CZC-8004 | 916603-07-1 | 98% |
|
| CZC-8004 is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases. | ||||
| T4618 | BGG463 | 890129-26-7 | 98% |
|
| BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively. | ||||
| T67847 | Imatinib impurities3 | 404844-11-7 | 98% |
|
| Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for ABL1 wt, KIT wt, PDGFRR wt, respectively. | ||||
| T22553 | Adaphostin | 241127-58-2 | 98% |
|
| This compound is a p210bcr/abl tyrosine kinase inhibitor (IC50 = 14 μM). | ||||
| T16750 | Rigosertib | 592542-59-1 | 98% |
|
| Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which... | ||||
| T6348 | NVP-BHG712 | 940310-85-0 | 98% |
|
| NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c... | ||||
| T4191 | Multi-kinase inhibitor 1 | 778274-97-8 | 98% |
|
| Multi-kinase inhibitor I is a Multi-kinase inhibitor. | ||||
| T2116 | AEE788 | 497839-62-0 | 98% |
|
| AEE788 has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors. | ||||
| T30855 | CGP77675 | 234772-64-6 | 98% |
|
| CGP77675 is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates and autophosphorylat... | ||||
| T22552L | AD57 | 1093380-42-7 | 98% |
|
| AD57 is a potent inhibitor of both c-Src and Abl with IC50 of 0.025 μM and 0.041 μM, respectively. | ||||
| T2094 | Danusertib | 827318-97-8 | 98% |
|
| Danusertib is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may ... | ||||
| T23128 | PD180970 | 287204-45-9 | 98% |
|
| PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit. PD180970 can be used in studies... | ||||
