| T60336 |
CCR4 antagonist 3-1
|
1957-01-3
|
98%
|
|
|
CCR4 antagonist 3-1 is a less active chemokine receptor 4 (CCR4) antagonist that inhibits [125I]TARC (thymus and activation-regulated chemokine) with an IC50 val...
|
| T13114 |
CCR2 antagonist 4
|
226226-39-7
|
98%
|
|
|
CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nM)...
|
| T77118 |
Plozalizumab
|
1610761-46-0
|
98%
|
|
|
Plozalizumab (MLN-1202) is a humanized selective and potent anti-CCR2 antibody.Plozalizumab has antitumor activity.Plozalizumab is used in the study of malignant...
|
| T77059 |
Leronlimab
|
674782-26-4
|
98%
|
Leronlimab
|
|
Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. leronlimumab has both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 vir...
|
| T14688 |
BMS CCR2 22
|
445479-97-0
|
98%
|
|
|
BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.
|
| TN1599 |
Eburicoic acid
|
560-66-7
|
98%
|
|
|
Eburicoic acid (ZINC4655149) exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage and can be used in...
|
| T4674 |
SB297006
|
58816-69-6
|
98%
|
|
|
SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. ...
|
| T11699 |
J-113863
|
353791-85-2
|
|
|
|
J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against...
|
| T5384 |
RS 504393
|
300816-15-3
|
|
|
|
RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).
|
| T6016 |
Maraviroc
|
376348-65-1
|
100%
|
|
|
Maraviroc (Selzentry) is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc i...
|
| T7624 |
DAPTA
|
106362-34-9
|
100%
|
|
|
DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.
|
| T10712 |
CCR2 antagonist 3
|
1380100-86-6
|
100%
|
|
|
CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.
|
| T9942 |
WAY-639418
|
643042-43-7
|
100%
|
|
|
WAY-639418 has potential anti-inflammatory and anti-HIV activity and can be used to study CCR5-mediated inflammatory and immunomodulatory diseases.
|
| T21870 |
C-021
|
864289-85-0
|
100.00%
|
|
|
C 021 dihydrochloride is a potent CCR4 antagonist. C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) dihydrochloride potently in...
|
| T30260 |
AZD-5672
|
780750-65-4
|
95.58%
|
|
|
AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7...
|
| T9983 |
CCR8 antagonist 1
|
723304-76-5
|
97.33%
|
|
|
CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.
|
| T3435 |
Vicriviroc maleate
|
599179-03-0
|
97.51%
|
|
|
Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50...
|
| T14909 |
CCX140
|
1100318-47-5
|
97.58%
|
|
|
CCX140 (CCX140-B) (CCX140-B) is an antagonist of CCR2.
|
| T24700 |
R243
|
688352-84-3
|
97.86%
|
|
|
R243 is CCR8 signaling and chemotaxis inhibitor.
|
| TQ0103 |
INCB3344
|
1262238-11-8
|
98.2%
|
|
|
INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8 nM...
|
