CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.

カタログ番号	製品名
TQ0053	Fadraciclib	CYC065 is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM).
T13202L	Trilaciclib	Trilaciclib is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6, respectively).
T13425	(1S,3R,5R)-PIM447 dihydrochloride	(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).
TN1663	Ganoderic acid DM	Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 ...
T12617	(R)-CR8 trihydrochloride	(R)-CR8 trihydrochloride is a potent inhibitor CDK1/2/5/7/9.
T4051	LDC4297	LDC4297 is a potent and selective CDK7 inhibitor.
T13058	T025	T025 是一种泛 CLK 抑制剂，对 CLK1-4 的 Kd 分别为 4.8、0.096、6.5、0.61 和 0.074 nM。 T025 在血液学和实体癌细胞系中表现出抗增殖活性，IC50 为 30-300 nM。 T025 可用于 MYC 驱动疾病的研究。
T13696	FN-1501-propionic acid	FN-1501-propionic acid and a CRBN ligand have been used to design PROTAC CDK2/9 degrader . FN-1501-propionic acid is a CDK2/9 ligand for PROTAC.
T11655	Indomethacin-D4	Indomethacin-D4 is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for huma...
T64373	CDK1-IN-2	CDK1-IN-2 is a CDK1 inhibitor with IC50 of 5.8 μM. A broad-spectrum kinase profiling of CDK1-IN-2 revealed nonselective inhibition of several kinases.
T11723	JNJ-39758979 dihydrochloride	JNJ-39758979 dihydrochloride is a selective, orally active, and high-affinity histamine H 4 receptor antagonist, with K i s of 12.5, 5.3, and 25 nM for human, mo...
T14990	CDK12-IN-3	CDK12-IN-3 is a selective CDK12 inhibitor (IC50: 491 nM in an enzymatic assay).
T14136	AG-024322	AG-024322 is a potent ATP-competitive inhibitor of pan-CDK against cell cycle kinases CDK1, CDK2, and CDK4(Ki values in the 1-3 nM range)
T10743	CDK9-IN-11	CDK9-IN-11 is a potent CDK9 inhibitor. CDK9-IN-11 is the ligand for the PROTAC CDK9 Degrader-1 [1].
T13627	CP-10	CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells inclu...
T13309	Voruciclib hydrochloride	Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).
TMA1743	Ergosterol peroxide	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
T10382	AS2863619 free base	AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells. It is a potent, orally active CDK8 ...
T12355	Palbociclib-d8	Palbociclib D8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active inhibitor of CDK4 and CDK6 (IC50s of 11 and 16 nM, respectively)....
TN4411	Lappaol F	1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. 2. Lap...
T15730	Ribociclib hydrochloride	Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It is over 1,000-fold less potent against the cyclin B/CDK1...
T11656	Indoramin D5	Indoramin D5 is a piperidine antiadrenergic agent. Indoramin D5 is deuterium labeled Indoramin.
TN3247	7-O-Prenylscopoletin	7-O-Prenylscopoletin and cedrelopsin show high antiproliferative activities against cancer cell lines.
T10836	CLK1-IN-1	CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).
T10465	Atuveciclib S-Enantiomer	Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) is a potent and selective CDK9 inhibitor, which inhibits CDK9 / CycT1 with an IC 50 of 16 nM.
T11309	FMF-04-159-2	FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. FMF-04-159-2 is a covalent CDK14 inhibitor.
TL0017	Aristolactam AIIIa	Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of plate...
T14914	Cdk1/2 Inhibitor III	Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor (IC50: 2.1 μM for CDK1/cyclin B).
T10745	CDK9-IN-7	CDK9-IN-7 is a highly selective and orally active CDK9/cyclin T inhibitor (IC50: 11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD: 148 nM; CDK6/c...
T14915	CDK12-IN-E9	CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux. It has a weak bind...
TN4394	Kobophenol A	Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
T10727	Cdc7-IN-5	Cdc7-IN-5 is a potent inhibitor of Cdc7 kinase. Cdc7, a serine-threonine protein kinase enzyme, is essential for the initiation of DNA replication in the cell cy...
T10735	CDK4/6/1 Inhibitor	CDK4/6/1 Inhibitor is a CDK4/6 inhibitor (IC50s: 3 and 1 nM).
T16038	Men 10376	Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.
T10747	CDK9-IN-9	CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).
TN3673	Clausine Z	Clausine Z exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro.
T2653	SB1317	SB1317 is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3).
T15204	EHT 1610	EHT 5372 is a strong DYRK’s family kinases of inhibitor (IC50s: 0.22, 0.28 nM for DYRK1A and DYRK1B, respectively).
T11632	IIIM-290	IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).
T6837	Flavopiridol	Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4...
TN3802	Dehydrodiconiferyl alcohol	Dehydrodiconiferyl alcohol shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. Dehydrodiconiferyl alcohol c...
T6139	A-674563	A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
T9446	KB-0742 dihydrochloride	KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.
TN1728	Hellebrigenin	Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. H...
T10744L2	SEL120-34A monohydrochloride	SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC 50 s of...
TN1664	Ganoderic acid H	Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting i...
T10546	Bio-THZ1	bio-THZ1 is a biotinylated version of THZ1. THZ1 is a selective and irreversibly covalent CDK7 inhibitor (IC50: 3.2 nM).
T10737	CDK4/6-IN-3	CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.
TN4263	Isoangustone A	Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
T10724	Cdc7-IN-1	Cdc7-IN-1 is a highly selective and ATP competitive inhibitor of Cdc7 kinase (IC50: 0.6 nM at 1 mM ATP). It potently inhibits Cdc7 activity in cancer cells and e...