| T14072 |
A-443654
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552325-16-3
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A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
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| T2356 |
Ro-3306
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872573-93-8
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RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...
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| T2193 |
2-Chloropyrazine
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14508-49-7
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2-Chloropyrazine is used in chemical industry.
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| T1855 |
ZCL278
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587841-73-4
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ZCL278 is a selective Cdc42 GTPase inhibitor.
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| TN1664 |
Ganoderic acid H
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98665-19-1
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Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting i...
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| T4293 |
THZ531
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1702809-17-3
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THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).
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| T14943 |
CGP60474
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164658-13-3
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CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits ...
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| T19831 |
Sodium Oxamate
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565-73-1
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Sodium Oxamate (Oxamic acid sodium salt) is an LDH inhibitor that specifically inhibits LDHA. Sodium Oxamate has antitumor activity and induces cell cycle arrest...
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| T10728 |
AS-0141
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1402057-88-8
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100%
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AS-0141 (Cdc7-IN-6) is a potent Cdc7 kinase inhibitor (IC50=4 nM) with anti-tumor activity.
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| T7093 |
Rafoxanide
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22662-39-1
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100%
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Rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer. Rafoxanide is a salicylanilide used as an anthelmintic. It is used to treat fluke, hookwo...
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| T10744 |
SEL120-34A
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1609522-33-9
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100%
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SEL120-34A is a selective and ATP-competitive inhibitor of CDK8 with IC50s of 4.4 nM, 10.4 nM and 1070 nM for CDK8/CycC, CDK19/CycC and CDK9/cycT. SEL120-34A pos...
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| T25125 |
AZA197
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1249398-09-1
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100%
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AZA197 (AZA-197) is a selective Cdc42 inhibitor. It acts by inhibiting primary colon cancer growth and prolonging survival in a preclinical mouse xenograft model...
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| T8796 |
CAN508
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140651-18-9
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100%
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CAN508 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. It is also a competitive inhibitor of Cdk2-cyclin E with respect to ATP, wi...
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| T8230 |
PNU112455A hydrochloride
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21886-12-4
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100%
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PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively.
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| T60152 |
AZ5576
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2751721-40-9
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100%
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AZ5576 is a potent and highly selective CDK9 inhibitor. AZ5576 can be used for the research of Hematological Malignancy [1].
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| T39608 |
Cirtuvivint
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2143917-62-6
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100%
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Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor that can be used to study arthritis.
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| T8972 |
FIT-039
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1113044-49-7
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100%
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FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μ...
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| T8378 |
AS2863619
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2241300-51-4
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100%
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AS2863619 is an orally active inhibitor of cyclin-dependent kinase 8 (CDK8) and CDK19 (IC50s of 0.61 nM and 4.28 nM, respectively).
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| T2095 |
Seliciclib
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186692-46-6
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100%
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Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E (IC50: 0.1 μM). It also inhibits Cdk7/cyclin H, Cdk5/p35, and Cdc2/cyclin B (IC50s: 0.49/0.16/0.6...
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| T10773 |
CF53
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1808160-52-2
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100%
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CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to b...
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