T14919 |
CDKI-73
|
1421693-22-2
|
98.11%
|
|
CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The in...
|
T10744L |
SEL120-34A HCl
|
1609452-30-3
|
98.13%
|
|
SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectively), ...
|
T10745 |
CDK9-IN-7
|
2369981-71-3
|
98.19%
|
|
CDK9-IN-7 is a highly selective and orally active CDK9/cyclin T inhibitor (IC50: 11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD: 148 nM; CDK6/c...
|
T10659 |
Ca2+ channel agonist 1
|
1402821-24-2
|
98.21%
|
|
Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor...
|
T4051 |
LDC4297
|
1453834-21-3
|
98.25%
|
|
LDC4297 (LDC044297) is a potent and selective CDK7 inhibitor.
|
T9138 |
Indirubin-3′-oxime
|
667463-82-3
|
98.26%
|
|
Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
|
T15204 |
EHT 1610
|
1425945-60-3
|
98.27%
|
|
EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively. EHT 1610 has an inhibitory effect on ...
|
T16391 |
ON-013100
|
865783-95-5
|
98.27%
|
|
ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.
|
T6199 |
Ribociclib
|
1211441-98-3
|
98.27%
|
|
Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor (IC50:10/39 nM).
|
T1830 |
BX795
|
702675-74-9
|
98.32%
|
|
BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respect...
|
T9636 |
Dalpiciclib
|
1637781-04-4
|
98.32%
|
|
Dalpiciclib (SHR-6390) is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4 nM and 9.9 nM, respective...
|
T2679 |
BMS-265246
|
582315-72-8
|
98.33%
|
|
BMS-265246 is a potent and selective CDK1/2 inhibitor.
|
T35332 |
THZ1 2HCl
|
2095433-94-4
|
98.33%
|
|
THZ1 2HCl (THZ1 Dihydrochloride) is a selective, covalent, and allosteric inhibitor of CDK7 with an IC50 of 3.2 nM. THZ1 2HCl has antiproliferative effects on a ...
|
T6028 |
PF 477736
|
952021-60-2
|
98.34%
|
|
PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CS...
|
T2517 |
SCH900776
|
891494-63-6
|
98.35%
|
|
SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.
|
T14367 |
AZ1495
|
2196204-23-4
|
98.36%
|
|
AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. W...
|
T72057 |
H1k
|
|
98.38%
|
|
H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulat...
|
T11961 |
MBM-55S
|
2083624-07-9
|
98.38%
|
|
MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer ce...
|
T4227 |
SB1317 hydrochloride (1204918-72-8(free base))
|
T4227
|
98.39%
|
|
SB1317 hydrochloride (1204918-72-8(free base)) (TG-02 hydrochloride) is an effective inhibitor of CDK2/JAK2/FLT3 (IC50: 13/73/56 nM).
|
T24152 |
HTH-01-091
|
2000209-42-5
|
98.40%
|
|
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...
|