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COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.
Cat. No. 製品名 CAS No. Purity Chemical Structure
TN4635 Neoechinulin A 51551-29-2 98%
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the ...
TN4659 Nimbin 5945-86-8 98%
Nimbin is an anti-pyretic, can be used to treat arthritis, hypoglycaemia, peptic ulcers, anti-secretory activity, and it can also be used as an antibiotic. Nimbi...
TN1715 Guaiacin 36531-08-5 98%
(+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2.
TN3806 Dehydroglyasperin C 199331-35-6 98%
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
TN4675 Nortrachelogenin 34444-37-6 98%
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
TN4013 Esculentic acid 103974-74-9 98%
Esculentic acid has anti-inflammatory effect, it has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the ...
TN1581 Dihydroguaiaretic acid 66322-34-7 98%
Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress.
T16817 S-2474 158089-95-3 98%
S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (IC50s: 11 nM and 27 μM for COX-2 and COX-1 in human intact cells).
T11761 Tarlox-TKI 2135696-72-7 98%
Kinase inhibitor-1 is a kinase inhibitor.
TN5093 Taiwanhomoflavone A 265120-00-1 98%
Taiwanhomoflavone A is cytotoxic with ED50 values of 3.4, 1.0, 2.0 and 2.5 microg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colo...
TN1407 Artocarpin 7608-44-8 98%
Artocarpin has anti- bactericidal effect, can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells.
TN2641 15-Methoxypinusolidic acid 769928-72-5 98%
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
TN5264 Xanthoxyletin 84-99-1 98%
Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory ...
TN4307 Isolimonexic acid 73904-93-5 98%
Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.
TN3726 Cudraflavone B 19275-49-1 98%
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
T13160 Timegadine 71079-19-1 98%
Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM f...
T11605 (-)-Ibuprofenamide 121839-78-9 98%
(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.
TMA0291 Dehydroglyasperin D 517885-72-2 98%
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
TN1562 Dehydromiltirone 116064-77-8 98%
Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting NF...
TN4581 Moracin D 69120-07-6 98%
Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization o...
Neoechinulin A
TN4635
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the ...
Nimbin
TN4659
Nimbin is an anti-pyretic, can be used to treat arthritis, hypoglycaemia, peptic ulcers, anti-secretory activity, and it can also be used as an antibiotic. Nimbi...
Guaiacin
TN1715
(+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2.
Dehydroglyasperin C
TN3806
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
Nortrachelogenin
TN4675
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
Esculentic acid
TN4013
Esculentic acid has anti-inflammatory effect, it has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the ...
Dihydroguaiaretic acid
TN1581
Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress.
S-2474
T16817
S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (IC50s: 11 nM and 27 μM for COX-2 and COX-1 in human intact cells).
Tarlox-TKI
T11761
Kinase inhibitor-1 is a kinase inhibitor.
Taiwanhomoflavone A
TN5093
Taiwanhomoflavone A is cytotoxic with ED50 values of 3.4, 1.0, 2.0 and 2.5 microg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colo...
Artocarpin
TN1407
Artocarpin has anti- bactericidal effect, can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells.
15-Methoxypinusolidic acid
TN2641
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
Xanthoxyletin
TN5264
Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory ...
Isolimonexic acid
TN4307
Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.
Cudraflavone B
TN3726
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
Timegadine
T13160
Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM f...
(-)-Ibuprofenamide
T11605
(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.
Dehydroglyasperin D
TMA0291
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
Dehydromiltirone
TN1562
Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting NF...
Moracin D
TN4581
Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization o...
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