CaMK

CAMK, also written as CaMK, is an abbreviation for the Ca2+/calmodulin-dependent protein kinase class of enzymes. CAMKs are activated by increases in the concentration of intracellular calcium ions (Ca2+) and calmodulin. When activated, the enzymes transfer phosphates from ATP to defined serine or threonine residues in other proteins, so they are serine/threonine-specific protein kinases. Activated CAMK is involved in the phosphorylation of transcription factors and therefore, in the regulation of expression of responding genes. CAMK also works to regulate the cell life cycle (i.e. programmed cell death), rearrangement of the cell's cytoskeletal network, and mechanisms involved in the learning and memory of an organism.There are 2 common types of CAM Kinase proteins: specialized and multi-functional CAM kinases.

Cat. No.	製品名	CAS No.	Purity
T2697	KN-93	139298-40-1	98%
T2697	KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.
T6605	NH125	278603-08-0	98%
T6605	NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
TP1403L	Syntide 2 acetate(108334-68-5 free base)	TP1403L	98%
TP1403L	Syntide-2 acetate is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 μM).
T3777	Praeruptorin A	73069-27-9	98%
T3777	Praeruptorin A ((+)-Praeruptorin A) has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and...
TP1909L1	CALP2 acetate(261969-04-4 free base)	TP1909L1	98%
TP1909L1	CALP2 acetate is an antagonist of calmodulin showing high affinity for binding to the CaM EF-hand/Ca2+-binding site with a Kd of 7.9 µM. CALP2 acetate potently i...
T3650	STO-609 acetate	1173022-21-3	98%
T3650	STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for the AT...
TP2310	Autocamtide-2-related inhibitory peptide	167114-91-2
TP2310	Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.
T16791	Rottlerin	82-08-6
T16791	Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKC...
T1222	Trifluoperazine dihydrochloride	440-17-5	100%
T1222	Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
TP1216	CaM kinase II inhibitor TFA salt	TP1216	100%
TP1216	CaM kinase II inhibitor TFA salt (Autocamtide-2-related inhibitory peptide (TFA)) is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.
T2159	CaMKP Inhibitor	52789-62-5	96.55%
T2159	CaMKP Inhibitor can inhibit CaMKP.
TP1271L	Calmodulin-Dependent Protein Kinase II 290-309 acetate		96.7%
TP1271L	Calmodulin-Dependent Protein Kinase II 290-309 acetate is an effective antagonist of Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM).
TP1921L1	Autocamtide-2-related inhibitory peptide, myristoylated acetate(201422-04-0 free base)	TP1921L1	97.03%
TP1921L1	Autocamtide-2-related inhibitory peptide, myristoylated acetate is a CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibit...
TQ0137	A-484954	142557-61-7	97.47%
TQ0137	A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.
T4185	Lavendustin C	125697-93-0	97.77%
T4185	lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.
TP1217L	Autocamtide 2 TFA(129198-88-5 free base)	TP1217L	98%
TP1217L	Autocamtide 2 TFA is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). Autocamtide 2 TFA can be used in the CaMKII...
T1158	Phenoxybenzamine hydrochloride	63-92-3	98.04%
T1158	Phenoxybenzamine hydrochloride (NCI-c01661) is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihyp...
T10667	Calmidazolium chloride	57265-65-3	98.06%
T10667	Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist (Kd = 3 nM), antagonizing CaM-dependent phosphodiesterase(IC50 = 0.15 μM) and calmodulin-induc...
TN1008	Psoralenoside	905954-17-8	98.17%
TN1008	Psoralenoside is a natural product isolated from the fruits of Psoralea corylifolia, shows estrogen-like activity, osteoblastic proliferation accelerating activi...
T14860	CaMKII-IN-1	1208123-85-6	98.35%
T14860	CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor (IC50: 63 nM). It has significantly high selectivity against CaMKIV, p38a, MLCK, Akt1, and PKC.