| T0275 |
Meticrane
|
1084-65-7
|
98%
|
|
|
Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.
|
| T4811 |
D-Alanine
|
338-69-2
|
98%
|
|
|
Alanine is a nonessential amino acid made in the body from the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and a...
|
| T4059 |
Selamectin
|
220119-17-5
|
|
|
|
Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in ...
|
| T50082 |
Org 25543
|
363628-88-0
|
|
|
|
Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.
|
| T5225 |
Hypotaurine
|
300-84-5
|
|
|
|
Hypotaurine (2-Aminoethanesulfinic acid), functioning as an intermediate in the biosynthesis of taurine from cysteine within astrocytes, acts as an endogenous in...
|
| T16533 |
Picrotin
|
21416-53-5
|
97.11%
|
|
|
Picrotin is an inhibitor of glycine receptors. Picrotin blocks α2 GlyR, α1 GlyR, and α3 GlyR and can be used in studies about neurotransmission.
|
| T13059 |
T16Ainh-A01
|
552309-42-9
|
98%
|
|
|
T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 µM),and functions as a calcium-activated ...
|
| T0019 |
Betaine chloride
|
590-46-5
|
98%
|
|
|
Betaine chloride (Betaine hydrochloride) is an acidic form of betaine, a vitamin-like substance observed in grains and other foods; gains the amplification of DN...
|
| T7638 |
NPPB
|
107254-86-4
|
98%
|
|
|
NPPB is a chloride channel blocker with IC50 of 80 nM .
|
| T16535 |
Picrotoxinin
|
17617-45-7
|
98.07%
|
|
|
Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant p...
|
| T36585 |
Isodeoxycholic Acid
|
566-17-6
|
98.12%
|
|
|
Isodeoxycholic Acid is a bile acid that is formed via epimerization of deoxycholic acid by intestinal bacteria. It has a greater critical micelle concentration t...
|
| T15233 |
Endovion
|
265646-85-3
|
98.31%
|
|
|
Endovion (NS3728) is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.
|
| T1125 |
Shikonin
|
517-89-5
|
98.54%
|
|
|
Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-...
|
| T15192 |
Eact
|
461000-66-8
|
98.62%
|
|
|
Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception an...
|
| T26630 |
Ani9
|
356102-14-2
|
98.72%
|
|
|
Ani9 is a high selective blocker of Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) with an IC50 of 77 nM and can be used in studies about ANO1 and the tre...
|
| T6307 |
Lubiprostone
|
136790-76-6
|
98.83%
|
|
|
Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.
|
| T21615 |
Guanidinoethyl sulfonate
|
543-18-0
|
98.9%
|
|
|
Guanidinoethyl sulfonate (Taurocyamine) is a competitive glycine receptor antagonist.
|
| T2498 |
Adjudin
|
252025-52-8
|
99.05%
|
|
|
Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.
|
| T12788 |
R(+)-IAA-94
|
54197-31-8
|
99.22%
|
|
|
R(+)-IAA-94 (R(+)-Methylindazone) is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R(+)-IAA-94 inhibits Nef-sdAb19 (single-domain antib...
|
| TN1035 |
Irisolidone
|
2345-17-7
|
99.46%
|
|
|
Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
|
