| T9573 |
GSK3685032
|
2170137-61-6
|
98%
|
|
|
GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM). The inhibitory effect is time-independent and reversible. GSK3685032 induces loss of DN...
|
| T5198 |
Bobcat339
|
2280037-51-4
|
|
|
|
Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
|
| T2169 |
Zebularine
|
3690-10-6
|
100%
|
|
|
Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as co...
|
| T0018 |
Procainamide hydrochloride
|
614-39-1
|
100%
|
|
|
Procainamide Hydrochloride (Procapan) is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog ...
|
| T11469 |
GSK-3484862
|
2170136-65-7
|
100%
|
|
|
GSK-3484862 is a non-covalent Dnmt1 inhibitor. It induces DNA hypomethylation to against cancer.
|
| T8967 |
SW155246
|
420092-79-1
|
97.79%
|
|
|
SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF...
|
| T16287 |
Neurodazine
|
937807-66-4
|
98.01%
|
|
|
Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Neurodazine promotes differentiation by activating Wnt...
|
| T7194 |
CM-272
|
1846570-31-7
|
98.21%
|
|
|
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
|
| T3089 |
6-Thioguanine
|
154-42-7
|
98.75%
|
|
|
6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
|
| T60322 |
Procainamide
|
51-06-9
|
98.86%
|
|
|
Procainamide (Novocainamide) is a specific and potent DNA methyltransferase 1 ( DNMT1 ) inhibitor. Procainamide is a Class 1A antiarrhythmic agent. Procainamide ...
|
| T24871 |
TFMB-(S)-2-HG
|
1445703-64-9
|
98.88%
|
|
|
TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase. Additionally, it significantly inhibits the EglN prolyl h...
|
| T1508 |
Decitabine
|
2353-33-5
|
99.17%
|
|
|
Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic a...
|
| T1904 |
SGI-1027
|
1020149-73-8
|
99.18%
|
|
|
SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027(SGI1027) against DNMT...
|
| T26972 |
Cedazuridine
|
1141397-80-9
|
99.46%
|
|
|
Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.
|
| T7840 |
2',3',5'-triacetyl-5-Azacytidine
|
10302-78-0
|
99.48%
|
|
|
2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.
|
| T7718 |
5-Fluoro-2'-deoxycytidine
|
10356-76-0
|
99.5%
|
|
|
5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .
|
| T2495 |
Lomeguatrib
|
192441-08-0
|
99.62%
|
|
|
Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
|
| T10840L |
CM-579
|
1846570-40-8
|
99.62%
|
|
|
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
|
| TNU0425 |
2’-Deoxy-2’-fluoro-β-D-arabinocytidine hydrochloride
|
25183-22-6
|
99.69%
|
|
|
2’-Deoxy-2’-fluoro-β-D-arabinocytidine hydrochloride is a cytosine nucleoside analog with inhibitory effects on DNA methyltransferase , with potential antimetabo...
|
| T7457 |
5-Methyl-2'-deoxycytidine
|
838-07-3
|
99.69%
|
|
|
5-Methyl-2'-deoxycytidine (5MedCyd) is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.
|
