| T40187 |
GNF2133
|
2561414-56-8
|
98%
|
|
|
GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.
|
| T36707 |
ML 315
|
1440251-53-5
|
98%
|
|
|
ML 315 is a selective Clk and DYRK inhibitor with potential anticancer activity for the study of neurological disorders.
|
| T14980 |
CLK-IN-T3
|
2109805-56-1
|
98%
|
|
|
CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.
|
| T26632 |
AnnH31
|
241809-12-1
|
100%
|
|
|
AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 μM.AnnH31 can be used as a probe to confirm the involve...
|
| T1711 |
Harmine
|
442-51-3
|
100%
|
|
|
Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.
|
| T23186 |
ProINDY
|
719277-30-2
|
97.19%
|
|
|
ProINDY (Pro-indy) is a potent DYRK inhibitor that activates NFAT for the study of Down syndrome.
|
| T15579 |
INDY
|
1169755-45-6
|
98.15%
|
|
|
INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
|
| T15204 |
EHT 1610
|
1425945-60-3
|
98.27%
|
|
|
EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively. EHT 1610 has an inhibitory effect on ...
|
| T24152 |
HTH-01-091
|
2000209-42-5
|
98.40%
|
|
|
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...
|
| T10827 |
CK2/ERK8-IN-1
|
1085822-09-8
|
98.82%
|
|
|
CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds t...
|
| T2670 |
ML167
|
1285702-20-6
|
98.85%
|
|
|
ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
|
| T11447 |
GNF4877
|
2041073-22-5
|
99.11%
|
|
|
GNF4877 is a potent DYRK1A and GSK3β inhibitor (IC50s: 6 nM and 16 nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and in...
|
| T2811 |
Harmine hydrochloride
|
343-27-1
|
99.45%
|
|
|
Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus.
|
| T15422 |
GSK-626616
|
1025821-33-3
|
99.48%
|
|
|
GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a...
|
| T6257 |
AZ191
|
1594092-37-1
|
99.65%
|
|
|
AZ191（IC50 of 17 nM） is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK2, r...
|
| T61360 |
ARN25068
|
2649882-80-2
|
99.71%
|
|
|
ARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses...
|
| T2431 |
ID-8
|
147591-46-6
|
99.77%
|
|
|
ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.
|
| T22012 |
7BIO
|
916440-85-2
|
99.77%
|
|
|
7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kin...
|
| T72039 |
CLK1-IN-3
|
2922550-28-3
|
99.79%
|
|
|
Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A. CLK1-IN-3 also showed highly e...
|
| T11960 |
MBM-55
|
2083622-09-5
|
99.98%
|
|
|
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing...
|
