Dopamine Receptor

Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). Dopamine receptors activate different effectors through not only G-protein coupling, but also signaling through different protein (dopamine receptor-interacting proteins) interactions.

カタログ番号	製品名
T12476	Pimozide-d4	Pimozide D4 is a deuterium labeled Pimozide.
T2564	Cis-(Z)-Flupentixol dihydrochloride	Flupenthixol dihydrochloride is a dopamine receptor antagonist.
T0338	Minaprine	Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
T13245	UCSF924	UCSF924 is a potent and specific agonist of dopamine D4 receptor (DRD4) partial (EC50: 4.2 nM, Ki: 3 nM).
T10837L	Clocapramine	Clocapramine is a D2 and 5-HT2A receptors antagonist.
T10681	Cariprazine D6	Cariprazine D6 (RGH-188 D6) is a deuterium-labeled Cariprazine. Cariprazine is an antipsychotic agent (D3 receptors, Ki: 0.085 nM; D2 receptors, Ki: 0.49 nM).
T15100	Desmethyl cariprazine	Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (K...
T12606	Quinpirole Hydrochloride	Quinpirole Hydrochloride is a high-affinity dopamine D2/D3 receptor agonist.
T13468	(±)-Epibatidine	(±)-Epibatidine is an agonist of nicotinic. (±)-Epibatidine is an agonist of neuronal nAChR.
TQ0175	Dexpramipexole	Dexpramipexole (KNS-760704, R-(+)-Pramipexole) is a neuroprotective agent and weak non-ergoline dopamine agonist.
T13463L2	Dihydrexidine hydrochloride	Dihydrexidine hydrochloride is a full efficacy D1-like dopamine receptor (D1/D5) agonist (IC50: 10 nM for D1 receptor). It also shows potent antiparkinsonian act...
T67729	UCM-1306	UCM-1306 is a potent and orally active allosteric modulator (PAM) of human dopamine D1 receptor. UCM-1306 could increase the maximal effect of endogenous dopamin...
T11799L	L-745870	L-745870 is a high-affinity and selective human dopamine D4 receptor antagonist (Ki: 0.43 nM). L-745870 has excellent brain penetration. It considerably weaker D...
T10612	Brexpiprazole S-oxide	Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM an...
T13240	U91356	U91356 is an agonist of the dopamine receptors.
T3086	Mesoridazine Besylate	Mesoridazine (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a m...
T14088	ABT-670	ABT-670 is a selective agonist of dopamine D4 receptor. For human D4, ferret D4, and rat D4, the EC50 values are 89 nM, 160 nM, and 93 nM , respectively.
T13463L	Dihydrexidine	Dihydrexidine is a full efficacy D1-like dopamine receptor (D1/D5) agonist (IC50: 10 nM for D1 receptor). It also shows potent antiparkinsonian activity.
T12861L	SB-277011 dihydrochloride	SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D...
T12676	(Rac)-Rotigotine hydrochloride	(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.
T16511	PF2562	PF2562 is a dopamine D1 ligand. It is used as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor (Ki: 113 nM). PF2562 shows activity aga...
T13652	Dicarbine	Double carbene can be used for the study of schizophrenia and alcoholism. It can block dopamine receptors in various parts of the brain and prevent the reduction...
T15117	Didesmethyl cariprazine	Cariprazine is an antipsychotic drug candidate. It shows high affinity for the D3 and D2 receptors, and moderate affinity for the 5-HT1A receptor. Didesmethyl ca...
T10213	A-437203	A-437203 is a selective D3 receptor antagonist (Kis: 71, 1.6, and 6220 nM for D2, D3, and D4 receptors).
T7341	Diclofensine	Diclofensine inhibits the uptake of serotonin, noradrenaline and dopamine.
T9237	Rotigotine	Rotigotine is an antiparkinson agent and dopamine receptor agonist.
T15744	Levophacetoperane hydrochloride	Levophacetoperane inhibits in vitro in a competitive manner. It also can norepinephrine uptake and dopamine uptake.
T1769	Pardoprunox	Pardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials studying the...
T6142	PD128907 HCl	PD128907 HCl 是一种有效的选择性多巴胺 D3 受体激动剂，EC50 为 0.64 nM，选择性是多巴胺 D2 受体的 53 倍。
T13387	Zatebradine	Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 µM).
TN1424	Bacopaside X	Bacopaside X (9.06 μM) showed binding affinity towards the D1 receptor.
T3426	Bacoside A	Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotect...
T12288	Odapipam	Odapipam is a selective and high affinity antagonist of benzazepine dopamine D1 receptor (Kd of 0.18 nM).
T13898	SPD-473 citrate	SPD-473 citrate is an inhibitior of serotonin/dopamine/norepinephrine reuptake.
TN2856	13-Hydroxyisobakuchiol	Delta3,2-Hydroxylbakuchiol, a monoamine transporter inhibitor involved in regulating dopaminergic and noradrenergic neurotransmission and may have represented po...
T13570	Benzamide Derivative 1	Benzamide Derivative 1, extracted from patent EP0213775A1 (compound 18), may be useful in the treatment of gastrointestinal disorders.
T1476L	Pramipexole dihydrochloride	Pramipexole dihydrochloride could be used to treat Parkinson disease.
T21667	FAUC-365	FAUC-365 is a D3 dopamine receptor agonist.
T12252	NRA-0160	NRA-0160 is a selective antagonist of dopamine D4 receptor(Ki of 0.48 nM)
T10611	Brexpiprazole S-oxide D8	Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole. Brexpiprazole is...
T10908	CY 208-243	CY 208-243 is a selective dopamine D1 receptor agonist with anti-Parkinson disease activity.
T15339	Foscarbidopa	Foscarbidopa is a prodrug of Carbidopa. It acts as a dopamine receptor agonist.
T2S1397	L-Stepholidine	L-Stepholidine, which has dual actions on dopamine D1 and D2 receptors, attenuates heroin self-administration and cue-induced reinstatement. It also elicits anti...
TQ0140	Sumanirole maleate	Sumanirole maleate (U-95666E) is a highly selective full agonist of the D2 receptor (ED50: 46 nM).
T4007	Eticlopride hydrochloride	Eticlopride, an antipsychotic, is a Selective dopamine D2/D3 receptor antagonist (Ki: 0.5/0.16 nM).
T22508	3-CPMT	dopamine uptake inhibitor
T15270	Fananserin	Fananserin is an effective, selective and oral active antagonist of 5-HT2 (Ki = 0.37 nM for the rat 5-HT2A). Fananserin is an antagonist of human D4 receptor (Ki...
T10683	Carmoxirole hydrochloride	Carmoxirole (EMD 45609) hydrochloride is a selective, peripherally acting agonist of dopamine D2 receptor with antihypertensive activities in vivo.
T9827	Carfenazine	carfenazine targets the Dopamine receptor and is used for schizophrenia research.
T27677	JNJ-37822681	JNJ-37822681 is the first compound that allows the evaluation of the potential value of fast D(2) antagonism for the treatment of bipolar disorder and schizophre...