| T7175 |
Alflutinib mesylate
|
2130958-55-1
|
98%
|
|
|
Alflutinib mesylate (AST2818 mesylate) ,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.
|
| T1761 |
PD153035 hydrochloride
|
183322-45-4
|
98%
|
|
|
PD153035 hydrochloride (ZM 252868) is a effective and selective inhibitor of EGFR (Ki: 5.2 pM, IC50: 29 pM); few influence against FGFR, PGDFR, InsR, CSF-1, and ...
|
| T0078L |
Lapatinib ditosylate monohydrate
|
388082-78-8
|
98%
|
|
|
Lapatinib ditosylate (Lapatinib tosilate) monohydrate is a tyrosine kinase receptor inhibitor used in the therapy of advanced breast cancer and other solid tumor...
|
| T60064 |
WAY-270360
|
476633-98-4
|
98%
|
|
|
WAY-270360 (N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide) is a sirtuin modulator and an epidermal growth factor receptor (EGFR) inhibitor.
|
| T11160 |
EGFR-IN-5
|
2225887-26-1
|
98%
|
|
|
EGFR-IN-5 is a selective inhibitor of EGFR. The IC50s for EGFR, EGFR(L858R), EGFR(L858R/T790M), and EGFR(L858R/T790M/C797S) are 10.4, 1.1, 34, 7.2 nM, respective...
|
| T1431 |
Khellin
|
82-02-0
|
98%
|
|
|
Khellin (Methafrone) is a vasodilator that also has bronchodilatory action.
|
| T60076 |
Oritinib
|
2035089-28-0
|
98%
|
|
|
Oritinib (SH-1028) is an inhibitor of EGFR with IC50s of 18, 0.7, 4, 0.1, 1.4 and 0.89 nM for EGFR (wt), EGFR (L858R), EGFR (L861Q), EGFR (L858R/T790M), EGFR (d7...
|
| T5437 |
Gefitinib-based PROTAC 3
|
2230821-27-7
|
98%
|
|
|
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(...
|
| T21853 |
(E)-AG 556
|
133550-41-1
|
98%
|
|
|
AG 556 is a selective inhibitor of EGFR and blocks LPS-induced TNF-α production.
|
| T34602 |
Selatinib
|
1275595-86-2
|
98%
|
|
|
Selatinib is an orally active and potent dual inhibitor of EGFR and ErbB2 with anticancer activity that inhibits the growth of NCI-N87 tumor cells.
|
| T61191 |
EAI001
|
892772-75-7
|
98%
|
|
|
EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.EAI00...
|
| T3659 |
Zorifertinib
|
1626387-80-1
|
98%
|
|
|
Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor. The IC50 values were 0.2, 0.3 and 0.2 nM for EGFR L858...
|
| T10531 |
BGB-102
|
807640-87-5
|
98%
|
|
|
BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3, which may be useful in the study of macular deg...
|
| T22833 |
H-9 dihydrochloride
|
116700-36-8
|
98%
|
|
|
H-9 dihydrochloride is a potent protein kinase (PKA) inhibitor.H-9 Dihydrochloride significantly reduces the excitatory response to 5-HT at low concentrations.H-...
|
| T11162 |
EGFR-IN-8
|
2407957-87-1
|
98%
|
|
|
EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLC....
|
| T63732 |
EGFR-IN-3
|
|
98%
|
|
|
EGFR-IN-3 is an EGFR inhibitor with potential antitumour activity.EGFR-IN-3 inhibits EGFRwt-TK and induces apoptosis (cell death), which can cause cells to block...
|
| T3870 |
Cyasterone
|
17086-76-9
|
98%
|
|
|
Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promising a...
|
| T76890 |
Petosemtamab
|
2213450-26-9
|
98%
|
Petosemtamab
|
|
Petosemtamab (MCLA 158) is a highly potent monoclonal antibody against EGFR (Kd: 0.22 nM) and LGR5 (Kd: 0.86 nM). Petosemtamab promotes EGFR signaling disruption...
|
| T76796 |
Patritumab
|
1262787-83-6
|
98%
|
|
|
Patritumab (U3-1287) is an anti-HER3 monoclonal antibody with potential antitumor activity and inhibits phosphorylation of EGFR, HER2, HER3, ERK, and AKT.Patritu...
|
| T22272 |
Lifirafenib
|
1446090-79-4
|
98%
|
|
|
Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E...
|
