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Endothelin Receptor

There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation of intracellular-free calcium, which constricts the smooth muscles of the blood vessels, raising blood pressure, or relaxes the smooth muscles of the blood vessels, lowering blood pressure, among other functions.
Cat. No. 製品名 CAS No. Purity Chemical Structure
TP1220L Carperitide acetate 1366000-58-9 98%
Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate)is a 28-amino acid hormone. Carperitide acetate is normally produced and sec...
TQ0259 Atrasentan 173937-91-2 98%
Atrasentan (ABT-627) (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
T10595 BQ-788 173326-37-9 98%
BQ-788 is a selective and potent ETB receptor antagonist with potential hypertensive activity.BQ-788 inhibits ET-1 binding to ETB receptors and inhibits exogenou...
T21790 BMS 182874 hydrochloride 1215703-04-0
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
T19309L1 Endothelin 1 (swine, human) acetate T19309L1
Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor...
T6264 Bosentan 147536-97-8 100%
Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endotheli...
T14219 Aminaftone 14748-94-8 96.31%
Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and can be used to study hypertension and systemic sclerosis.
T15595L IRL-1620 acetate T15595L 96.64%
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.
T5458 Darusentan 171714-84-4 97.26%
Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries
T31640 Enrasentan 167256-08-8 97.96%
Enrasentan (sb-217242) is a mixed antagonist of ET(A) and ET(B) receptors that reduces blood pressure, prevents cardiac hypertrophy, and protects myocardial func...
T12924 Sitaxsentan 184036-34-8 97.99%
Sitaxsentan (TBC-11251) is A selective endothelin A (ETA) receptor antagonist. Endothelin is an effective vasoconstrictor. Sitaxsentan blocks the binding of endo...
T6792 BQ-123 136553-81-6 98%
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
T6672 Sitaxsentan sodium 210421-74-2 98%
Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors.
T15596 IRL 2500 169545-27-1 98.29%
IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.
T26841 BMS 182874 153042-42-3 98.38%
BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for E...
T3474 RO 46-8443 175556-12-4 98.5%
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms...
TQ0270 Atrasentan hydrochloride 195733-43-8 98.64%
Atrasentan hydrochloride (ABT-627 hydrochloride) is an antagonist of the endothelin receptor(IC50 = 55.1 μM for ETA).
T31605 Edonentan 210891-04-6 98.69%
Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.
T3194 Ro 46-2005 150725-87-4 98.8%
Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA recep...
T5355 Sparsentan 254740-64-2 98.81%
Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respective...
Carperitide acetate
TP1220L
Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate)is a 28-amino acid hormone. Carperitide acetate is normally produced and sec...
Atrasentan
TQ0259
Atrasentan (ABT-627) (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA).
BQ-788
T10595
BQ-788 is a selective and potent ETB receptor antagonist with potential hypertensive activity.BQ-788 inhibits ET-1 binding to ETB receptors and inhibits exogenou...
BMS 182874 hydrochloride
T21790
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
Endothelin 1 (swine, human) acetate
T19309L1
Endothelin 1 (swine, human) acetate is a synthetic peptide with the sequence of human and swine Endothelin 1. Endothelin 1 is a potent endogenous vasoconstrictor...
Bosentan
T6264
Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endotheli...
Aminaftone
T14219
Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and can be used to study hypertension and systemic sclerosis.
IRL-1620 acetate
T15595L
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.
Darusentan
T5458
Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries
Enrasentan
T31640
Enrasentan (sb-217242) is a mixed antagonist of ET(A) and ET(B) receptors that reduces blood pressure, prevents cardiac hypertrophy, and protects myocardial func...
Sitaxsentan
T12924
Sitaxsentan (TBC-11251) is A selective endothelin A (ETA) receptor antagonist. Endothelin is an effective vasoconstrictor. Sitaxsentan blocks the binding of endo...
BQ-123
T6792
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
Sitaxsentan sodium
T6672
Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors.
IRL 2500
T15596
IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.
BMS 182874
T26841
BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for E...
RO 46-8443
T3474
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms...
Atrasentan hydrochloride
TQ0270
Atrasentan hydrochloride (ABT-627 hydrochloride) is an antagonist of the endothelin receptor(IC50 = 55.1 μM for ETA).
Edonentan
T31605
Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.
Ro 46-2005
T3194
Ro 46-2005 is a synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA recep...
Sparsentan
T5355
Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respective...
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