FABP

The fatty-acid-binding proteins (FABPs) are a family of transport proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes. Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR. The FABPs are intracellular carriers that “solubilize” the endocannabinoid anandamide (AEA), transporting AEA to the breakdown by FAAH, and compounds that bind to FABPs block AEA breakdown, raising its level. The cannabinoids (THC and CBD) are also discovered to bind human FABPs (1, 3, 5, and 7) that function as intracellular carriers, as THC and CBD inhibit the cellular uptake and catabolism of AEA by targeting FABPs. Competition for FABPs may in part or wholly explain the increased circulating levels of endocannabinoids reported after consumption of cannabinoids. Levels of fatty-acid-binding protein have been shown to decline with ageing in the mouse brain, possibly contributing to age-associated decline in synaptic activity.

Cat. No.	製品名	CAS No.	Purity
T4534	BMS-309403	300657-03-8	99.54%
BMS-309403 is an effective, selective and cell-permeable inhibitor of fatty acid binding protein 4 (FABP4) with a Ki of less than 2 nM.
T78960	FABP4-IN-2		98%
FABP4-IN-2 (Compd 10g), a selective and orally active FABP4 inhibitor, exhibits K i values of 0.51 μM for FABP4 and 33.01 μM for FABP3, demonstrating its specifi...

Cat. No.

製品名

CAS No.

Purity

Chemical Structure

T4534

BMS-309403

300657-03-8

99.54%

BMS-309403 is an effective, selective and cell-permeable inhibitor of fatty acid binding protein 4 (FABP4) with a Ki of less than 2 nM.

T78960

FABP4-IN-2

98%

FABP4-IN-2 (Compd 10g), a selective and orally active FABP4 inhibitor, exhibits K i values of 0.51 μM for FABP4 and 33.01 μM for FABP3, demonstrating its specifi...