| T14997 |
Conteltinib
|
1384860-29-0
|
98%
|
|
|
Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK, and Pyk2.Conteltinib exhibits significant inhibition of FAK, overcomes hy...
|
| T16266 |
NAMI-A
|
201653-76-1
|
98%
|
|
|
NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.
|
| T9973 |
FAK-IN-7
|
19948-85-7
|
98%
|
|
|
FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.
|
| T2465 |
PF-562271
|
717907-75-0
|
98%
|
|
|
PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).
|
| T9545 |
Compound 1T-0219 (SC)
|
383147-92-0
|
98%
|
|
|
Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620 c...
|
| T8544 |
Masitinib mesylate
|
1048007-93-7
|
98%
|
|
|
Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;PDGFRα...
|
| T77718 |
FAK-IN-10
|
491839-65-7
|
98%
|
|
|
FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively.
|
| T2314 |
PF-431396
|
717906-29-1
|
98%
|
|
|
PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).
|
| T2281 |
GSK2256098
|
1224887-10-8
|
|
|
|
GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.
|
| T5S0761 |
Nitidine chloride
|
13063-04-2
|
96.59%
|
|
|
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
|
| T6997 |
SU6656
|
330161-87-0
|
97%
|
|
|
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
|
| T24730 |
Roslin 2 bromide
|
29574-21-8
|
97.07%
|
|
|
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effect...
|
| T13564 |
AZ7550
|
1421373-99-0
|
97.07%
|
|
|
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
|
| T5480 |
BI-4464
|
1227948-02-8
|
97.43%
|
|
|
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
|
| T24642 |
YH-306
|
1373764-75-0
|
97.87%
|
|
|
YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
|
| T7119 |
Y15
|
4506-66-5
|
98%
|
|
|
Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, b...
|
| T1918 |
NVP-TAE 226
|
761437-28-9
|
98.07%
|
|
|
NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, ...
|
| T64167 |
Ifebemtinib
|
1227948-82-4
|
98.07%
|
|
|
Ifebemtinib (BI-853520) is an orally active and potent inhibitor of adhesion plaque kinase (FAK) (IC50=1 nM) with anti-tumour activity that inhibits globule form...
|
| T64167L |
BI-853520 FA
|
|
98.40%
|
|
|
BI-853520 FA (Ifebemtinib FA) is an orally active and potent inhibitor of adhesion patch kinase (FAK) with anticancer and antiproliferative activity for the stud...
|
| T21768 |
PF-562271 hydrochloride
|
939791-41-0
|
98.52%
|
|
|
PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent f...
|
