FLAP

FLAP (Arachidonate 5-lipoxygenase-activating protein) is an integral membrane protein, it facilitates the transfer of the substrate arachidonic acid (AA) to 5-lipoxygenase (5-LO) to produce leukotrienes (LTs), and is shown to be indispensable for cellular LT biosynthesis. FLAP transfers arachidonic acid to 5-LOX protein, thereby enabling this enzyme to efficiently produce oxidized lipid products (mainly eicosanoids) that are important in cell growth, differentiation and death particularly apoptosis.

Cat. No.	製品名	CAS No.	Purity
T11487	Fiboflapon	936350-00-4	97.01%
T11487	Fiboflapon (GSK2190915) is an orally available and effective 5-lipoxygenase-activating protein (FLAP) inhibitor that binds FLAP with a titer of 2.9 nM and inhibi...
T16087	Quiflapon	136668-42-3	98.88%
T16087	Quiflapon (MK-591) causes cell apoptosis. Quiflapon is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor (IC50: 1.6 nM in a FLAP bindin...
T9023	Atuliflapon	2041075-86-7	99.13%
T9023	Atuliflapon (AZD5718) is a novel 5-Lipoxygenase Activating Protein(FLAP) inhibitor for Treatment of Coronary Artery Disease.
T10314	AM103	1147872-22-7	99.21%
T10314	AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).
T8844	Diflapolin	724453-98-9	99.23%
T8844	Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and ...
T6893	MK-886	118414-82-7	99.78%
T6893	MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagoni...
TQ0098	Quiflapon sodium	147030-01-1	98%
TQ0098	Quiflapon sodium (MK591) is a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP).
T81181	SEH/FLAP-IN-1		98%
T81181	sEH/FLAP-IN-1 (Compound 46A) serves as a dual inhibitor targeting both sEH and FLAP. It effectively suppresses 5-LOX product formation with an EC50 of 11 nM in S...
T79389	LTB4-IN-2		98%
T79389	LTB4-IN-2 (Compound 6x) is a selective inhibitor of Leukotriene B4 (LTB4), acting by specifically targeting the 5-Lipoxygenase-activating protein (FLAP) with an ...
T79135	FEN1-IN-7	824983-90-6	98%
T79135	FEN1-IN-7 (compound 16), a selective Flap endonuclease-1 (FEN1) inhibitor with an IC50 of 18 nM, plays a role in DNA damage repair in mammalian cells. Additional...
T79134	FEN1-IN-6	824983-84-8	98%
T79134	FEN1-IN-6 (compound 9) is a potent Flap endonuclease-1 (FEN1, IC50 = 10 nM) inhibitor, crucial for DNA damage repair in mammalian cells, and additionally targets...
T78192	FEN1-IN-5	824983-93-9	98%
T78192	FEN1-IN-5 (compound 12A) is a potent Flap endonuclease-1 (FEN1) inhibitor with an IC50 value of 12 nM, playing a role in DNA repair mechanisms [1].